| Autor: |
Decensi, A., Bonanni, B., Maisonneuve, P., Serrano, D., Omodei, U., Varricchio, C., Cazzaniga, M., Lazzeroni, M., Rotmensz, N., Santillo, B., Sideri, M., Cassano, E., Belloni, C., Muraca, M., Segnan, N., Masullo, P., Costa, A., Monti, N., Vella, A., Bisanti, L., D'Aiuto, G., Veronesi, U., Schitulli, Francesco, Deliso, Maria, Omodei, Umberto, Ramazzotto, Francesca, Corini, Silvia, Pecorelli, Sergio, Daldos, Cristina, Melis, Gianbenedetto, Pilloni, Monica, Artioli, Fabrizio, Guerzoni, Roberta, Sciacchitano, Salvatore, Grasso, Daniela, Torrioli, Donatello, Bravi, Stefano, Corrado, Gemma, Biamonte, Rosalbino, Segnan, Nereo, Ponti, Antonio, Marti, Elvira, Gonzales, Galina, Campagnoli, Carlo, Massobrio, Marco, Ambrogio, Simona, Gallo, Mario, Sismondi, Piero, Biglia, Nicoletta, Uicic, E, Bottini, Alberto, Allevi, Giovanni, Andreis, Daniele, Rosselli del Turco Marco, Muraca Maria Grazia, Zeccarelli, Maurizia, Iossa, Anna, Brancato, Beniamino, Belluardo, Donatella, Valenzano, Mario, Bogliolo, Stefano, Fortunato, Tiziana, Pardi, Giorgio, Ferrari, Maria, Waldis, Francesca, Veronesi, Umberto, Bonanni, Bernardo, Cazzaniga, Massimiliamo, Lazzeroni, Matteo, Serrano, Davide, Varricchio Maria Clara, Feroce, Irene, Rotmensz, Nicole, Maisonneuve, Patrick, Santillo, Barbara, Bazolli, Barbara, Goldhirsch, Aron, Sideri, Mario, Di Pace Raffaella, Moroni, Simona, Zamperini, Paola, Viale, Giuseppe, Cassano, Enrico, Latronico, Antuono, Meneghetti, Lorenza, Di Nubila Brunella, Pizzamiglio, Maria, D’Aiuto, Giuseppe, Oliviero, Pasquale, Oliviero, Giovanna, Riccone, Giuseppina, Gustavino, Claudio, Centurioni Maria Grazia, Ferrando, Liliana, De Maria Enrica, Zandonini, Gianfranco, Mangioni, Costantino, Giussani Maria Elena, Di Carlo Costantino, Nappi, Carmine, Mapelli, Carlo, Infantino, Carmelo, Bacchi Modena Alberto, Sgarabotto Maria Paola, Valitutto, Simona, Costa, Alberto, Scoccia, Elisabetta, Genazzani, Andrea, Gambacciani, Marco, Pepe, Antonia, Vacca, Francesca, Monti, Nadia, Tumolo, Salvatore, Cascinu, Stefano, Michiara, Maria, Ravaioli, Alberto, Desiderio, Franco, Fabbri, Carla, Pini, Emanuela, Vella, Alessandro, Fabi Linda Maria, Corrado, Nunziata, Bastianelli, Carlo, Rapiti, Stefania, Colafrancesco, Francesca, Ferrazzi, Enrico, Bombelli Maria Vittoria, Ciminera, Nadia, Cetin, Irene, Quaranta, Stefano, Incoronato, Pasquale, Gioffréwalter, Tripodi, Alessia, Vescio, Filippo, Pacquola Maria Grazia, Piccione, Emilio, Pietropolli, Adalgisa, Belloni, Carlo, Piol, Francesca, Sangiorgi, Barbara, Masullo, Pietro, Di Feo Gemma, Speranza, Mariangela, Ronsini, Salvatore, Bisanti, Luigi |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Annals of oncology : official journal of the European Society for Medical Oncology. 24(11) |
| ISSN: |
1569-8041 |
| Popis: |
Postmenopausal hormone replacement therapy (HRT) relieves menopausal symptoms and may decrease mortality in recently postmenopausal women, but increases breast cancer risk. Low-dose tamoxifen has shown retained activity in phase-II studies.We conducted a phase-III trial in 1884 recently postmenopausal women on HRT who were randomly assigned to either tamoxifen, 5 mg/day, or placebo for 5 years. The primary end point was breast cancer incidence.After 6.2 ± 1.9 years mean follow-up, there were 24 breast cancers on placebo and 19 on tamoxifen (risk ratio, RR, 0.80; 95% CI 0.44-1.46). Tamoxifen showed favorable trends in luminal-A tumors (RR, 0.32; 95% CI 0.12-0.86), in HRT users5 years (RR, 0.35; 95% CI 0.15-0.82) and in women completing at least 12 months of treatment (RR, 0.49; 95% CI 0.23-1.02). Serious adverse events did not differ between placebo and tamoxifen, including, respectively, coronary heart syndrome (6 versus 4), cerebrovascular events (2 versus 5), VTE (2 versus 5) and uterine cancers (3 versus 1). Vasomotor symptoms were 50% more frequent on tamoxifen.The addition of low-dose tamoxifen to HRT did not significantly reduce breast cancer risk and increased climacteric symptoms in recently postmenopausal women. However, we noted beneficial trends in some subgroups which may deserve a larger study. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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