Comparison of PI-RADS Versions 2.0 and 2.1 for MRI-based Calculation of the Prostate Volume
| Autor: | Sungmin Woo, Anton S. Becker, Hebert Alberto Vargas, Daniel Stocker, Hedvig Hricak, Soleen Ghafoor, Pamela Ines Causa Andrieu, Natalie Gangai |
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| Přispěvatelé: | University of Zurich, Ghafoor, Soleen |
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Accuracy and precision Wilcoxon signed-rank test Intraclass correlation 610 Medicine & health 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Prostate Radiologists medicine Humans 2741 Radiology Nuclear Medicine and Imaging Radiology Nuclear Medicine and imaging Retrospective Studies Mathematics medicine.diagnostic_test business.industry 10042 Clinic for Diagnostic and Interventional Radiology Prostatic Neoplasms Magnetic resonance imaging Magnetic Resonance Imaging Ellipsoid PI-RADS medicine.anatomical_structure 030220 oncology & carcinogenesis Nuclear medicine business Volume (compression) |
| DOI: | 10.5167/uzh-192163 |
| Popis: | Prostate gland volume (PGV) should be routinely included in MRI reports of the prostate. The recently updated Prostate Imaging Reporting and Data System (PI-RADS) version 2.1 includes a change in the recommended measurement method for PGV compared to version 2.0. The purpose of this study was to evaluate the agreement of MRI-based PGV calculations with the volumetric manual slice-by-slice prostate segmentation as a reference standard using the linear measurements per PI-RADS versions 2.0 and 2.1. Furthermore, to assess inter-reader agreement for the different measurement approaches, determine the influence of an enlarged transition zone on measurement accuracy and to assess the value of the bullet formula for PGV calculation.Ninety-five consecutive treatment-naive patients undergoing prostate MRI were retrospectively analyzed. Prostates were manually contoured and segmented on axial T2-weighted images. Four different radiologists independently measured the prostate in three dimensions according to PI-RADS v2.0 and v2.1, respectively. MRI-based PGV was calculated using the ellipsoid and bullet formulas. Calculated volumes were compared to the reference manual segmentations using Wilcoxon signed-rank test. Inter-reader agreement was calculated using intraclass correlation coefficient (ICC).Inter-reader agreement was excellent for the ellipsoid and bullet formulas using PI-RADS v2.0 (ICC 0.985 and 0.987) and v2.1 (ICC 0.990 and 0.994), respectively. The median difference from the reference standard using the ellipsoid formula derived PGV was 0.4 mL (interquartile range, -3.9 to 5.1 mL) for PI-RADS v2.0 (p = 0.393) and 2.6 mL (interquartile range, -1.6 to 7.3 mL) for v2.1 (p0.001) with a median difference of 2.2 mL. The bullet formula overestimated PGV by a median of 13.3 mL using PI-RADS v2.0 (p0.001) and 16.0 mL using v2.1 (p0.001). In the presence of an enlarged transition zone the PGV tended to be higher than the reference standard for PI-RADS v2.0 (median difference of 4.7 mL; p = 0.018) and for v2.1 (median difference of 5.7 mL, p0.001) using the ellipsoid formula.Inter-reader agreement was excellent for the calculated PGV for both methods. PI-RADS v2.0 measurements with the ellipsoid formula yielded the most accurate volume estimates. The differences between PI-RADS v2.0 and v2.1 were statistically significant although small in absolute numbers but may be of relevance in specific clinical scenarios like prostate-specific antigen density calculation. These findings validate the use of the ellipsoid formula and highlight that the bullet formula should not be used for prostate volume estimation due to systematic overestimation. |
| Databáze: | OpenAIRE |
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