Genomic Changes of Chagas Disease Vector, South America
| Autor: | José-Enrique O'Connor, Rubén Pérez, Hernán Bermúdez, Santiago Mas-Coma, Paula Nicolini, Francisco Panzera, Virginia Rose, Tatiana Tellez, María Dolores Bargues, Jean-Pierre Dujardin, María Noel Caraccio |
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| Předmět: |
Microbiology (medical)
Chagas disease Male Epidemiology Heterochromatin Allopatric speciation lcsh:Medicine Disease Vectors lcsh:Infectious and parasitic diseases geographic polymorphism chemistry.chemical_compound Triatoma infestans medicine Animals lcsh:RC109-216 Triatoma Genetics holocentric chromosomes Autosome biology Research flow cytometry lcsh:R fungi heterochromatin South America biology.organism_classification medicine.disease Infectious Diseases chemistry Evolutionary biology Vector (epidemiology) genome size Female Triatominae DNA |
| Zdroj: | Scopus-Elsevier Emerging Infectious Diseases Emerging Infectious Diseases, Vol 10, Iss 3, Pp 438-446 (2004) |
| Popis: | We analyzed the main karyologic changes that have occurred during the dispersion of Triatoma infestans, the main vector of Chagas disease. We identified two allopatric groups, named Andean and non-Andean. The Andean specimens present C-heterochromatic blocks in most of their 22 chromosomes, whereas non-Andean specimens have only 4-7 autosomes with C-banding. These heterochromatin differences are the likely cause of a striking DNA content variation (approximately 30%) between Andean and non-Andean insects. Our study, together with previous historical and genetic data, suggests that T. infestans was originally a sylvatic species, with large quantities of DNA and heterochromatin, inhabiting the Andean region of Bolivia. However, the spread of domestic T. infestans throughout the non-Andean regions only involved insects with an important reduction of heterochromatin and DNA amounts. We propose that heterochromatin and DNA variation mainly reflected adaptive genomic changes that contribute to the ability of T. infestans to survive, reproduce, and disperse in different environments. |
| Databáze: | OpenAIRE |
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