Methylchloroisothiazolinone/methylisothiazolinone and methylisothiazolinone allergies can be detected by 200 ppm of methylchloroisothiazolinone/methylisothiazolinone patch test concentration
| Autor: | Maria Leiva-Salinas, Angelica Maria Bouret, Laura Frances, Juan Francisco Silvestre, Irene Marin-Cabanas |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Allergy Dermatology Cosmetics behavioral disciplines and activities Methylchloroisothiazolinone methylisothiazolinone chemistry.chemical_compound Young Adult Internal medicine Methylisothiazolinone mental disorders medicine Prevalence Immunology and Allergy Humans Prospective Studies Prospective cohort study business.industry Preservatives Pharmaceutical Patch test Methylchloroisothiazolinone Middle Aged Patch Tests medicine.disease nervous system diseases Causality Thiazoles chemistry Dermatitis Occupational Contact allergy Spain Dermatitis Allergic Contact Female business human activities Contact dermatitis |
| Zdroj: | Dermatitis : contact, atopic, occupational, drug. 25(3) |
| ISSN: | 2162-5220 |
| Popis: | Background Methylchloroisothiazolinone/methylisothiazolinone (MCI/MI) and methylisothiazolinone (MI) contact allergies are rising dramatically. Moreover, 100 ppm of MCI/MI patch test might not detect an important number of MCI/MI and MI allergies. Objectives This study aimed to present the prevalence of contact allergy to both preservatives in an area of Spain and to investigate if 100 ppm of MCI/MI is an adequate concentration for a proper diagnosis. Methods A prospective study was conducted from October 2011 to September 2013. All patients were patch tested with the Spanish baseline series (containing 100 ppm of MCI/MI) and with 200 ppm of MCI/MI and 2000 ppm of MI. Results A total of 490 patients were patch tested. The MCI/MI prevalence was 10% and increased from 7.8% in last term of 2011 to 14.3% in the first 9 months of 2013. The MI prevalence was 4.5% and increased from 1% to 7.7% in the same period. One hundred parts per million of MCI/MI could not diagnose 24.5% of MCI/MI allergies. All MI allergies were detected by 200 ppm of MCI/MI, whereas only 68.2% were positive to 100-ppm concentration. Conclusions For a correct diagnosis of MCI/MI and MI contact allergies, we advocate increasing the MCI/MI patch test concentration to 200 ppm along with a temporal inclusion of MI in the North American Contact Dermatitis Group baseline series. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|