A high menaquinone intake reduces the incidence of coronary heart disease

Autor: N.M. de Roos, M. L. Bots, Ivonne Sluijs, J. C. M. Witteman, Johanna M. Geleijnse, Y. T. van der Schouw, Joline W.J. Beulens, Gerrie-Cor M. Gast, D. E. Grobbee, P. H. M. Peeters
Přispěvatelé: Medical Oncology, Epidemiology, Epidemiology and Data Science, ACS - Diabetes & metabolism, ACS - Heart failure & arrhythmias, APH - Health Behaviors & Chronic Diseases
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Male
Nutrition and Disease
Endocrinology
Diabetes and Metabolism
food frequency questionnaire
Medicine (miscellaneous)
Coronary Disease
Cohort Studies
Eating
Risk Factors
Surveys and Questionnaires
Voeding en Ziekte
Matrix gla protein
Epidemiology
Prospective Studies
gamma-carboxyglutamic acid
Prospective cohort study
Netherlands
risk
Nutrition and Dietetics
biology
Incidence (epidemiology)
Smoking
Vitamin K 2
Vitamin K 1
Vitamins
Middle Aged
matrix gla protein
vascular calcification
Cardiology
Female
women
Cardiology and Cardiovascular Medicine
Cohort study
Canadian health claims
medicine.medical_specialty
vitamin-k
SDG 3 - Good Health and Well-being
Internal medicine
medicine
Humans
Aged
Proportional Hazards Models
VLAG
Global Nutrition
Wereldvoeding
phylloquinone intake
business.industry
Proportional hazards model
tissue
relative validity
Coronary heart disease
Diet
biology.protein
Energy Intake
business
Follow-Up Studies
Zdroj: Nutrition, Metabolism and Cardiovascular Diseases, 19(7), 504-510. Elsevier
Nutrition, Metabolism & Cardiovascular Diseases, 19(7), 504-510
Nutrition, Metabolism & Cardiovascular Diseases 19 (2009) 7
Gast, G C M, de Roos, N M, Sluijs, I, Bots, M L, Beulens, J W J, Geleijnse, J M, Witteman, J C, Grobbee, D E, Peeters, P H M & van der Schouw, Y T 2009, ' A high menaquinone intake reduces the incidence of coronary heart disease ', Nutrition, Metabolism and Cardiovascular Diseases, vol. 19, no. 7, pp. 504-510 . https://doi.org/10.1016/j.numecd.2008.10.004
ISSN: 0939-4753
DOI: 10.1016/j.numecd.2008.10.004
Popis: Background and Aim: Vitamin K dependent proteins have been demonstrated to inhibit vascular calcification. Data on the effect of vitamin K intake on coronary heart disease (CHD) risk, however, are scarce. To examine the relationship between dietary vitamins K1 and K2 intake, and its subtypes, and the incidence of CHD. Methods and Results: We used data from the Prospect-EPIC cohort consisting of 16,057 women, enrolled between 1993 and 1997 and aged 49-70 years, who were free of cardiovascular diseases at baseline. Intake of vitamin K and other nutrients was estimated with a food frequency questionnaire. Multivariate Cox proportional hazards models were used to analyse the data. After a mean ± SD follow-up of 8.1 ± 1.6 years, we identified 480 incident cases of CHD. Mean vitamin K1 intake was 211.7 ± 100.3 μg/d and vitamin K2 intake was 29.1 ± 12.8 μg/d. After adjustment for traditional risk factors and dietary factors, we observed an inverse association between vitamin K2 and risk of CHD with a Hazard Ratio (HR) of 0.91 [95% CI 0.85-1.00] per 10 μg/d vitamin K2 intake. This association was mainly due to vitamin K2 subtypes MK-7, MK-8 and MK-9. Vitamin K1 intake was not significantly related to CHD. Conclusions: A high intake of menoquinones, especially MK-7, MK-8 and MK-9, could protect against CHD. However, more research is necessary to define optimal intake levels of vitamin K intake for the prevention of CHD.
Databáze: OpenAIRE
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