Staphylococcal Osteomyelitis: Disease Progression, Treatment Challenges, and Future Directions
| Autor: | Gillian Sexton, Nicola Kavanagh, Jérôme P. Fennell, Sadhbh O'Rourke, Steven W. Kerrigan, Fergal J. O'Brien, Emily J. Ryan, Amro Widaa, Cathal J. Kearney, Kevin C. Cahill |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Epidemiology medicine.drug_class Staphylococcus 030106 microbiology Antibiotics Review medicine.disease_cause Staphylococcal infections Bone Infection 03 medical and health sciences Pharmacotherapy Staphylococcus epidermidis medicine Humans General Immunology and Microbiology biology business.industry Osteomyelitis Public Health Environmental and Occupational Health Staphylococcal Infections biology.organism_classification medicine.disease Anti-Bacterial Agents Infectious Diseases Staphylococcus aureus Host-Pathogen Interactions Immunology Disease Progression business |
| Zdroj: | Clinical Microbiology Reviews. 31 |
| ISSN: | 1098-6618 0893-8512 |
| Popis: | SUMMARY Osteomyelitis is an inflammatory bone disease that is caused by an infecting microorganism and leads to progressive bone destruction and loss. The most common causative species are the usually commensal staphylococci, with Staphylococcus aureus and Staphylococcus epidermidis responsible for the majority of cases. Staphylococcal infections are becoming an increasing global concern, partially due to the resistance mechanisms developed by staphylococci to evade the host immune system and antibiotic treatment. In addition to the ability of staphylococci to withstand treatment, surgical intervention in an effort to remove necrotic and infected bone further exacerbates patient impairment. Despite the advances in current health care, osteomyelitis is now a major clinical challenge, with recurrent and persistent infections occurring in approximately 40% of patients. This review aims to provide information about staphylococcus-induced bone infection, covering the clinical presentation and diagnosis of osteomyelitis, pathophysiology and complications of osteomyelitis, and future avenues that are being explored to treat osteomyelitis. |
| Databáze: | OpenAIRE |
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