Effects of pancragen on the differentiation of pancreatic cells during their ageing
| Autor: | V. O. Polyakova, G. H. Tolibova, Natalia Linkova, A. O. Durnova, T. V. Kvetnaia, I. M. Kvetnoy, S. I. Tarnovskaya, V. Kh. Khavinson |
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| Rok vydání: | 2013 |
| Předmět: |
endocrine system
medicine.medical_specialty endocrine system diseases Biology digestive system General Biochemistry Genetics and Molecular Biology Cell Line Internal medicine medicine Humans Pancreas Cellular Senescence Homeodomain Proteins geography geography.geographical_feature_category Nuclear Proteins Cell Differentiation General Medicine medicine.disease Islet medicine.anatomical_structure Endocrinology Homeobox Protein Nkx-2.2 Cell culture Cancer research Pancreatitis PDX1 PAX4 FOXA2 PAX6 Oligopeptides Transcription Factors |
| Zdroj: | Bulletin of experimental biology and medicine. 154(4) |
| ISSN: | 1573-8221 |
| Popis: | Expression of differentiation markers was found to be reduced during ageing of pancreatic cells. Tetrapeptide pancragen stimulates the expression of differentiation factors of acinar (Pdx1, Ptfl a) and islet of Langerhans (Pdx1, Pax6, Pax4, Foxa2, NKx2.2) cells in “young” and “aged” cultures. Differentiation of acinar and islet pancreatic cells induced by pancragen can be a mechanism underlying its anti-diabetic and anti-inflammatory effects. Thus, transcription factors that regulate differentiation of pancreatic cells are a pharmacological target for pancragen, which allows considering it as an effective tool in the treatment of diabetes mellitus and pancreatitis. |
| Databáze: | OpenAIRE |
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