Prevalence and clinical correlation of hepatitis E virus antibody in the patients’ serum samples from a tertiary care hospital in Thailand during 2015–2018
| Autor: | Thidarat Sisaeng, Wannee Kantakamalakul, Chutikarn Chaimayo, Atiporn Boonyai, Parisut Phumchan, Navin Horthongkham, Anchalee Thongput |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty viruses 030106 microbiology Seroprevalence Infectious and parasitic diseases RC109-216 Transplant Gastroenterology Organ transplantation Serology Tertiary Care Centers 03 medical and health sciences Seroepidemiologic Studies Pregnancy Virology Internal medicine Hepatitis E virus Prevalence medicine Humans Hepatitis Antibodies Hepatitis biology Research Incidence (epidemiology) Incidence virus diseases Thailand medicine.disease Hepatitis E Transplant Recipients digestive system diseases Cross-Sectional Studies 030104 developmental biology Infectious Diseases Immunoglobulin M HEV Immunoglobulin G biology.protein Female Antibody |
| Zdroj: | Virology Journal, Vol 18, Iss 1, Pp 1-11 (2021) Virology Journal |
| Popis: | Background Prevalence and incidence of hepatitis caused by HEV infection are usually higher in developing countries. This study demonstrated the HEV seroprevalence and incidence of HEV infection in patients with clinical hepatitis in a tertiary hospital in Thailand. Methods A laboratory-based cross-sectional study was conducted using 1106 serum samples from patients suspected of HEV infection sent to the Serology laboratory, Siriraj Hospital, for detecting HEV antibodies during 2015–2018. Prevalence of anti-HEV IgG and IgM antibodies in general patients, including organ transplant recipients and pregnant women in a hospital setting, were determined using indirect enzyme-linked immunosorbent assay (ELISA) kits. Comparison of laboratory data between groups with different HEV serological statuses was performed. Results HEV IgG antibodies were detected in 40.82% of 904 serum samples, while HEV IgM antibodies were detected in 11.75% of 1081 serum samples. Similar IgG and IgM antibody detection rates were found in pregnant women. Interestingly, anti-HEV IgM antibodies were detected in 38.5% of patients who underwent organ transplantation. Patients who tested positive for anti-HEV IgM antibodies had higher alanine aminotransferase levels than those who had not. In contrast, patients who tested positive for anti-HEV IgG had more elevated levels of total bilirubin than those who tested negative. Conclusions HEV seroprevalence and incidence in patients with clinical hepatitis were relatively high in the Thai population, including the pregnancy and organ transplant subgroups. The results potentially benefit the clinicians in decision-making to investigate HEV antibodies and facilitating proper management for patients. |
| Databáze: | OpenAIRE |
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