Interplay between viruses and bacterial microbiota in cancer development
| Autor: | Khiem C. Lam, Andrey Morgun, Dariia Vyshenska, Natalia Shulzhenko |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Carcinogenesis Immunology Biology medicine.disease_cause Viral infection Article 03 medical and health sciences Neoplasms medicine Genetics Immunology and Allergy 2.2 Factors relating to the physical environment 2.1 Biological and endogenous factors Animals Humans Microbiome Transkingdom interactions Aetiology Cancer Prevention Microbiota Viral Load medicine.disease Virology 030104 developmental biology Infectious Diseases Virus Diseases Virus-associated cancer Gene-Environment Interaction Cancer development Infection Oncogenic Viruses Oncovirus |
| Zdroj: | Seminars in immunology, vol 32, iss C |
| ISSN: | 1096-3618 |
| Popis: | During the last few decades we have become accustomed to the idea that viruses can cause tumors. It is much less considered and discussed, however, that most people infected with oncoviruses will never develop cancer. Therefore, the genetic and environmental factors that tip the scales from clearance of viral infection to development of cancer are currently an area of active investigation. Microbiota has recently emerged as a potentially critical factor that would affect this balance by increasing or decreasing the ability of viral infection to promote carcinogenesis. In this review, we provide a model of microbiome contribution to the development of oncogenic viral infections and viral associated cancers, give examples of this process in human tumors, and describe the challenges that prevent progress in the field as well as their potential solutions. |
| Databáze: | OpenAIRE |
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