Cervical dysplasia after renal transplantation: A retrospective cohort study

Autor: Mustafa Cosan Terek, Orkun Ilgen, Sevki Goksun Gokulu, Ahmet Bilgi, Seda Akgün Kavurmacı, Mehmet Kulhan, Huseyin Toz
Přispěvatelé: Ege Üniversitesi
Rok vydání: 2021
Předmět:
medicine.medical_specialty
hypertension
retrospective study
uterine cervicitis
medicine.medical_treatment
kidney transplantation
lcsh:Medicine
lcsh:Gynecology and obstetrics
Article
Organ transplantation
lupus erythematosus nephritis
Internal medicine
medicine
follow up
controlled study
Cumulative incidence
Clinical Investigation
cyclosporine
human
tacrolimus
lcsh:RG1-991
clinical article
azathioprine
hemodialysis
uterine cervix dysplasia
business.industry
adult
squamous intraepithelial lesion of the cervix
lcsh:R
mycophenolate mofetil
Obstetrics and Gynecology
Cancer
Immunosuppression
Retrospective cohort study
cervical dysplasia
renal transplantation
cohort analysis
medicine.disease
body mass
Transplantation
female
peritoneal dialysis
inflammation
Dysplasia
diabetes mellitus
uterine cervix cytology
Population study
business
Zdroj: Turkish Journal of Obstetrics and Gynecology, Vol 18, Iss 1, Pp 7-14 (2021)
Turkish Journal of Obstetrics and Gynecology
ISSN: 2149-9330
1307-699X
DOI: 10.4274/tjod.galenos.2021.28938
Popis: Objective: Since the first days of organ transplantation, it has been accepted that solid transplant recipients have a high risk of developing cancer. Chronic immunosuppression and environmental factors play a role in cancer development in recipients. In the present study, we tried to evaluate the cumulative incidence of cervical dysplasia after renal transplantation, risk factors for disease development, and the time until high-grade dysplasia occurred. Materials and Methods: A total of 50 patients with renal transplantation who presented for gynecologic follow-up was included in the study. The medical records of the patients were reviewed until the last clinical visit, their demographic characteristics, transplant history, gynecologic history, and gynecologic examination results (cervical cytology and histology reports) were reviewed. Results: Of the 50 women in the study population, 29 (58%; 95% confidence interval: 8.8-15.9) developed cervical dysplasia after the first transplant at a median follow-up of 7.8 (range: 4.6-12.9) years. Twenty-one women with benign cervical cytology before transplantation had evidence of low-grade intraepithelial lesions + after transplant (47% of these were within 2 years after transplant). During the follow-up, 8 women (18.2%) were diagnosed as having high-grade intraepithelial lesions + (within 5 years after transplantation). Conclusion: Renal transplant patients were found to have higher abnormal cervical cytology and histology rates than the normal population. © 2021, Turkish Society of Obstetrics and Gynecology. All rights reserved.
Databáze: OpenAIRE
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