Localised Ewing sarcoma/PNET of bone?prognostic factors and international data comparison
| Autor: | Samira Rifai, Mohammed O. Al-Shabanah, Yasser Khafaga, Mouhab Ayas, Derek Younge, Ayman Allam, Ibrahim Al-Fawaz, R. Derek T. Jenkin, Muhammad Yousuf Memon, Henrik Schultz |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Cancer Research medicine.medical_specialty Adolescent medicine.medical_treatment Saudi Arabia Bone Neoplasms Sarcoma Ewing Recurrence medicine Humans Neuroectodermal Tumors Primitive Child Small tumors Staging system Chemotherapy Tumor size business.industry Induction chemotherapy medicine.disease Ewing sarcoma / PNET Surgery Survival Rate Oncology El Niño Multivariate Analysis Pediatrics Perinatology and Child Health Female Sarcoma Radiology business |
| Zdroj: | Medical and Pediatric Oncology. 39:586-593 |
| ISSN: | 1096-911X 0098-1532 |
| Popis: | Background To determine if the distribution of prognostic factors accounted for the differences when the outcome for localised Ewing Sarcoma/PNET bone in Saudi Arabia was compared with results from countries with well developed health care systems. Procedure Retrospective analysis was undertaken of 163 consecutive patients of all ages, treated with radical intent at KFSHRC from 1975 to 1998. Standard chemotherapy was commenced in all patients. The local treatment modality was resection ± radiation in 30% and radiation treatment alone in 67%. Size data were available for 51 patients treated from 1994 to 1998, inclusive. One third of these patients had tumors with volume >500 ml. Results Three year survival significantly increased with the year of diagnosis, 1975–1988 45%; 1989–1993 55%; and 1993–1998 63% (P = 0.006). Favorable prognostic factors were age ≤14 (P = 0.07); site, distal extremity, and skull (P = 0.08); and volume ≤ 200 ml (P = 0.06). Secondary prognostic factors were response to induction chemotherapy, both histological, 100% necrosis, (P = 0.04) and clinical CR+PR, (P = 0.02). From 1994 to 1998, 3 year survival for tumors in the distal extremity and skull was 80% and for small tumors, 200 ml, 55%. Conclusions Overall survival progressively improved. From 1994 to 1998 the survival of patients with small tumors and/or favorable sites was similar to the best reported results. It was not possible to compare results by tumor size for large tumors, > 500 ml, due to the absence of data from elsewhere. A better staging system is required for the international comparison of results. Med Pediatr Oncol 2002;39:586–593. © 2002 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text