Branched Chain Amino Acid Supplementation to a Hypocaloric Diet Does Not Affect Resting Metabolic Rate but Increases Postprandial Fat Oxidation Response in Overweight and Obese Adults after Weight Loss Intervention

Autor: Chin Meng Khoo, Delicia Shu Qin Ooi, Jennifer Qiu Rong Ling, Eric Yin Hao Khoo, Melvin Khee-Shing Leow, Mary Foong-Fong Chong, Yung Seng Lee, E. Shyong Tai, Fang Yi Ong, Christiani Jeyakumar Henry, Chuen Seng Tan
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Male
branched chain amino acids (BCAA)
resting metabolic rate (RMR)
diet-induced thermogenesis (DIT)
respiratory quotient (RQ)
carbohydrate oxidation
lipid oxidation
hypocaloric diet
high-protein
weight loss
obese and overweight adults
Overweight
Weight loss
TX341-641
Nutrition and Dietetics
Middle Aged
Postprandial Period
Weight Reduction Programs
Postprandial
Treatment Outcome
Adipose Tissue
Diet
High-Protein
Female
medicine.symptom
Oxidation-Reduction
Adult
medicine.medical_specialty
Carbohydrate metabolism
Article
Young Adult
Lipid oxidation
Internal medicine
Weight Loss
medicine
Humans
Obesity
Caloric Restriction
business.industry
Nutrition. Foods and food supply
Calorimetry
Indirect
Respiratory quotient
Endocrinology
Basal metabolic rate
Dietary Supplements
Lean body mass
Basal Metabolism
business
Amino Acids
Branched-Chain
Food Science
Zdroj: Nutrients
Nutrients, Vol 13, Iss 4245, p 4245 (2021)
Nutrients; Volume 13; Issue 12; Pages: 4245
ISSN: 2072-6643
Popis: Background: Branched chain amino acids (BCAA) supplementation is reported to aid in lean mass preservation, which may in turn minimize the reduction in resting metabolic rate (RMR) during weight loss. Our study aimed to examine the effect of BCAA supplementation to a hypocaloric diet on RMR and substrate utilization during a weight loss intervention. Methods: A total of 111 Chinese subjects comprising 55 males and 56 females aged 21 to 45 years old with BMI between 25 and 36 kg/m2 were randomized into three hypocaloric diet groups: (1) standard-protein (14%) with placebo (CT), (2) standard-protein with BCAA, and (3) high-protein (27%) with placebo. Indirect calorimetry was used to measure RMR, carbohydrate, and fat oxidation before and after 16 weeks of dietary intervention. Results: RMR was reduced from 1600 ± 270 kcal/day to 1500 ± 264 kcal/day (p < 0.0005) after weight loss, but no significant differences in the change of RMR, respiratory quotient, and percentage of fat and carbohydrate oxidation were observed among the three diet groups. Subjects with BCAA supplementation had an increased postprandial fat (p = 0.021) and decreased postprandial carbohydrate (p = 0.044) oxidation responses compared to the CT group after dietary intervention. Conclusions: BCAA-supplemented standard-protein diet did not significantly attenuate reduction of RMR compared to standard-protein and high-protein diets. However, the postprandial fat oxidation response increased after BCAA-supplemented weight loss intervention.
Databáze: OpenAIRE
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