The risk and predictors for severe radiation pneumonitis in lung cancer patients treated with thoracic reirradiation

Autor: Jun Dang, Chengbo Ren, Tianlong Ji, Guang Li, Tingting Liu
Rok vydání: 2018
Předmět:
lcsh:Medical physics. Medical radiology. Nuclear medicine
Adult
Male
medicine.medical_specialty
Lung Neoplasms
Multivariate analysis
Side effect
lcsh:R895-920
medicine.medical_treatment
Radiosurgery
lcsh:RC254-282
Re-Irradiation
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Carcinoma
Non-Small-Cell Lung
medicine
Humans
Radiology
Nuclear Medicine and imaging
Lung cancer
Radiation Pneumonitis
Reirradiation
Aged
Retrospective Studies
Univariate analysis
Mean lung dose
Predictors
business.industry
Research
Radiotherapy Dosage
Common Terminology Criteria for Adverse Events
Middle Aged
Thoracic Neoplasms
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
medicine.disease
Small Cell Lung Carcinoma
Radiation therapy
Oncology
030220 oncology & carcinogenesis
Female
Radiotherapy
Intensity-Modulated
Radiology
Neoplasm Recurrence
Local
Radiotherapy
Conformal
business
Follow-Up Studies
Zdroj: Radiation Oncology (London, England)
Radiation Oncology, Vol 13, Iss 1, Pp 1-7 (2018)
ISSN: 1748-717X
Popis: Background Thoracic reirradiation (re-RT) is increasingly administered. However, radiation pneumonitis (RP) remains to be the most common side effect from retreatment. This study aimed to determine the risk and predictors for severe RP in patients receiving thoracic re-RT. Methods Sixty seven patients with lung cancer received thoracic re-RT for recurrent or metastatic disease. Three-dimensional conformal radiotherapy (3D-CRT)/intensity modulated radiotherapy (IMRT) was used for 60 patients, and stereotactic body radiation therapy (SBRT) was used in 7 patients. Deformable image registration (DIR) was performed to create a composite plan. Severe (grade ≥ 3) RP was graded according to Common Terminology Criteria for Adverse Events version 4.0. Results Eighteen patients (26.9%) developed grade ≥ 3 RP (17 of grade 3, and 1 of grade 4). In univariate analyses, V5 and mean lung dose (MLD) of initial RT or re-RT plans, V5 and V20 of composite plans, and the overlap between V5 of initial RT and V5 of re-RT plans/V5 of re-RT plans (overlap-V5/re-V5) were significantly associated with grade ≥ 3 RP (P
Databáze: OpenAIRE
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