Differences in maintenance of CD8+ and CD4+ bacteria-specific effector-memory T cell populations
| Autor: | Matthias Schiemann, Dirk H. Busch, Katharina M. Huster, Kathrin Linkemann, Verena Busch |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
CD4-Positive T-Lymphocytes
T cell Bacterial Toxins Immunology Epitopes T-Lymphocyte CD8-Positive T-Lymphocytes Biology Hemolysin Proteins Interferon-gamma Mice Interleukin 21 medicine Animals Immunology and Allergy Cytotoxic T cell IL-2 receptor Heat-Shock Proteins Mice Inbred BALB C Tumor Necrosis Factor-alpha Effector Intracellular parasite Listeria monocytogenes Cell biology Mice Inbred C57BL medicine.anatomical_structure Immunologic Memory Memory T cell CD8 |
| Zdroj: | European Journal of Immunology. 33:2875-2885 |
| ISSN: | 1521-4141 0014-2980 |
| Popis: | Our knowledge about the kinetics and dynamics of complex pathogen-specific CD8(+) T cell responses and the in vivo development of CD8(+) memory T cells has increased substantially over the past years; in comparison, relatively little is known about the CD4(+) T cell compartment. We monitored and directly compared the phenotypical changes of pathogen (Listeria monocytogenes)-specific CD8(+) and CD4(+) T cell responses under conditions leading to effective and long-lasting protective immunity. We found that the general kinetics of bacteria-specific CD8(+) and CD4(+) T cells during the effector and post-effector phases are synchronized. However, later during the memory phase, CD8(+) and CD4(+) T cell populations differ substantially. Whereas CD8(+) memory T cell populations with immediate effector function are readily detectable in lymphoid and non-lymphoid tissues and remain remarkably stable in size, antigen-specific CD4(+) effector-memory T cells decline continuously in frequency over time. These findings have important implications for the better understanding of the in vivo development of protective immunity towards intracellular pathogens. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text