The Role of D-allulose and Erythritol on the Activity of the Gut Sweet Taste Receptor and Gastrointestinal Satiation Hormone Release in Humans: A Randomized, Controlled Trial
| Autor: | Fabienne Teysseire, Valentine Bordier, Aleksandra Budzinska, Nathalie Weltens, Jens F Rehfeld, Jens J Holst, Bolette Hartmann, Christoph Beglinger, Lukas Van Oudenhove, Bettina K Wölnerhanssen, Anne Christin Meyer-Gerspach |
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| Rok vydání: | 2021 |
| Předmět: |
Male
INHIBITION Medicine (miscellaneous) gut sweet taste receptor SUGAR Fructose Satiation GLUCOSE Gastrointestinal Hormones gastric emptying APPETITE Glucagon-Like Peptide 1 gastrointestinal satiation hormones GLP-1 SECRETION Humans Peptide YY D-allulose D-PSICOSE Nutrition and Dietetics Science & Technology GLUCAGON-LIKE PEPTIDE-1 Cross-Over Studies Nutrition & Dietetics PYY digestive oral and skin physiology Water GLYCEMIC RESPONSES Erythritol lactisole Taste appetite-related sensations Tyrosine Female erythritol Cholecystokinin Life Sciences & Biomedicine hormones hormone substitutes and hormone antagonists INGESTION |
| Zdroj: | Teysseire, F, Bordier, V, Budzinska, A, Weltens, N, Rehfeld, J F, Holst, J J, Hartmann, B, Beglinger, C, Van Oudenhove, L, Wölnerhanssen, B K & Meyer-Gerspach, A C 2022, ' The Role of D-allulose and Erythritol on the Activity of the Gut Sweet Taste Receptor and Gastrointestinal Satiation Hormone Release in Humans : A Randomized, Controlled Trial ', Journal of Nutrition, vol. 152, no. 5, pp. 1228–1238, . https://doi.org/10.1093/jn/nxac026 |
| ISSN: | 1541-6100 |
| DOI: | 10.1093/jn/nxac026 |
| Popis: | BACKGROUND: Glucose induces the release of gastrointestinal (GI) satiation hormones, such as glucagon-like peptide-1 (GLP-1), and peptide tyrosine tyrosine (PYY) in part via the activation of the gut sweet taste receptor (T1R2/T1R3).OBJECTIVES: The primary objective was to investigate the importance of T1R2/T1R3 for the release of cholecystokinin (CCK), GLP-1 and PYY in response to D-allulose and erythritol by assessing the effect of the T1R2/T1R3 antagonist lactisole on these responses and as secondary objectives to study the effect of the T1R2/T1R3 blockade on gastric emptying, appetite-related sensations and GI symptoms.METHODS: In this randomized, controlled, double-blind, cross-over study, 18 participants (five men, mean ± SD BMI: 21.9 ± 1.7 kg/m2, age: 24 ± 4 y) received an intragastric administration of 25 g D-allulose, 50 g erythritol, or tap water, with or without 450 parts per million (ppm) lactisole, respectively, in six different sessions. 13C-sodium acetate was added to all solutions to determine gastric emptying. At fixed time intervals, blood and breath samples were collected, and appetite-related sensations and GI symptoms were assessed. Data were analyzed with linear mixed model analysis.RESULTS: D-allulose and erythritol induced a significant release of CCK, GLP-1 and PYY compared to tap water (all PHolm < 0.0001, dz > 1). Lactisole did not affect the D-allulose- and erythritol-induced release of CCK, GLP-1, and PYY (all PHolm > 0.1). Erythritol significantly delayed gastric emptying, increased fullness and decreased prospective food consumption compared to tap water (PHolm = 0.0002, dz = -1.05, PHolm = 0.0190, dz = 0.69 and PHolm = 0.0442, dz = -0.62, respectively).CONCLUSIONS: D-allulose and erythritol stimulate the secretion of GI satiation hormones in humans. Lactisole had no effect on CCK, GLP-1, and PYY release, indicating that D-allulose- and erythritol-induced GI satiation hormone release is not mediated via T1R2/T1R3 in the gut. Clinical Trial Registry number and website: Number: NCT04027283, Website: https://clinicaltrials.gov/ct2/show/NCT04027283?term=NCT04027283&draw=2&rank=1. |
| Databáze: | OpenAIRE |
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