Multiethnic Genome-Wide Association Study of Diabetic Retinopathy Using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control

Autor: Mark I. McCarthy, Weihua Meng, Brian L. Yaspan, M Imamura, Mark W. Christiansen, Niina Sandholm, Yii-Der Ida Chen, Sharon G. Adler, Lucia Sobrin, Craig L. Hanis, Valeriya Lyssenko, Shiro Maeda, Yang Hai, Paul Mitchell, Roberta McKean-Cowdin, Xiuqing Guo, John R. Sedor, David S. Siscovick, Sudha K. Iyengar, Heather Hancock, Jane Z. Kuo, Barbara E.K. Klein, David-Alexandre Tregouet, Elisabet Agardh, Kent D. Taylor, Andrew D. Morris, S. Mohsen Hosseini, Andrew D. Paterson, I-Te Lee, Wayne Huey-Herng Sheu, Emma Ahlqvist, Kathryn P. Burdon, Leif Groop, Ayellet V. Segrè, Samy Hadjadj, Samaneh Davoudi, Lynn K. Stanwyck, Emily Y. Chew, Xiaohui Li, Michael A. Grassi, Jie Jin Wang, Samuela Pollack, Albert V. Smith, Kyu Hyung Park, Michiaki Kubo, Mary Frances Cotch, Yucheng Jia, Ching J. Chen, Colin N. A. Palmer, Helen M. Colhoun, Alan D. Penman, R. Varma, Per-Henrik Groop, Tien Yin Wong, Barry I. Freedman, Eli Ipp, Alex S. F. Doney, Gavin Tan, Ronald Klein, Kaanan P. Shah, Jamie E Craig, Donald W. Bowden, Jerome I. Rotter, Robert P. Igo, Darryl Nousome, Ching-Yu Cheng, Michel Marre, Maggie C.Y. Ng, Latchezar Dimitrov, Jeeyun Ahn, Atsushi Takahashi, Richard A. Jensen, Aaron Leong, Jihye Kim, Iiro Toppila, Elizabeth J. Rossin, Alkes L. Price
Přispěvatelé: Diabetes and Obesity Research Program, University of Helsinki, Department of Medicine, Nefrologian yksikkö, Research Programs Unit, Clinicum, HUS Abdominal Center, Per Henrik Groop / Principal Investigator
Rok vydání: 2018
Předmět:
Blood Glucose
0301 basic medicine
Oncology
medicine.medical_specialty
Genotype
Endocrinology
Diabetes and Metabolism
LOCI
030209 endocrinology & metabolism
Genome-wide association study
VARIANTS
Polymorphism
Single Nucleotide
03 medical and health sciences
0302 clinical medicine
Meta-Analysis as Topic
RESOURCE
Internal medicine
Diabetes mellitus
REVEALS
Genetic variation
Internal Medicine
medicine
Humans
Genetic Predisposition to Disease
CHINESE PATIENTS
Allele
METAANALYSIS
POLYMORPHISMS
Glycemic
Glycated Hemoglobin
Diabetic Retinopathy
business.industry
Diabetic retinopathy
medicine.disease
PREVALENCE
3. Good health
SEVERITY
030104 developmental biology
Diabetes Mellitus
Type 2
3121 General medicine
internal medicine and other clinical medicine
Multiple comparisons problem
RISK-FACTORS
Medical genetics
Erratum
business
Genome-Wide Association Study
Protein Binding
Zdroj: Diabetes
2018, ' Multiethnic Genome-wide Association Study of Diabetic Retinopathy using Liability Threshold Modeling of Duration of Diabetes and Glycemic Control ', Diabetes . https://doi.org/10.2337/db18-0567
ISSN: 1939-327X
0012-1797
DOI: 10.2337/db18-0567
Popis: To identify genetic variants associated with diabetic retinopathy (DR), we performed a large multiethnic genome-wide association study. Discovery included eight European cohorts (n = 3,246) and seven African American cohorts (n = 2,611). We meta-analyzed across cohorts using inverse-variance weighting, with and without liability threshold modeling of glycemic control and duration of diabetes. Variants with a P value
Databáze: OpenAIRE
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