Glutathione S-Transferase M1 and T1 Gene Polymorphisms in Patients with Chronic Plaque-Type Psoriasis: A Case-Control Study
| Autor: | Mutlu Karkucak, Esma Uslu, Teoman Erdem, Hakan Turan, Sebnem Ozemri Sag, Tahsin Yakut, Gokhan Ocakoglu, Berna Solak |
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| Přispěvatelé: | Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı., Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı., Ocakoğlu, Gökhan, Sağ, Şebnem Özemri, Yakut, Tahsin, AAH-8355-2021, AAH-5180-2021, Solak, B, Karkucak, M, Turan, H, Ocakoglu, G, Sag, SO, Uslu, E, Yakut, T, Erdem, T, Sakarya Üniversitesi/Tıp Fakültesi/Dahili Tıp Bilimleri Bölümü, Solak, Berna |
| Rok vydání: | 2015 |
| Předmět: |
Male
Turkey Glutathione transferase Genomic DNA Bioinformatics Gastroenterology law.invention Cancer risk Sensitivity law Genotype Outpatient clinic Dimethyl Fumarate Fumaric Acid Multiple Sclerosis Polymerase chain reaction Skin biology Gene polymorphisms General Medicine Medicine general & internal Glutathione S-transferase Cohort Female Human Adult medicine.medical_specialty Population Case control study Case-control studies Major clinical study Polymorphism genetic Article Association Glutathione transferase M1 Psoriasis Internal medicine Multiplex polymerase chain reaction Genetic susceptibility Genetics medicine Humans Glutathione S-transferase M1 Aged Psoriasis vulgaris Original Paper Genetic polymorphism business.industry Glutathione S-transferase T1 Case-control study medicine.disease DNA isolation Glutathione transferase T1 Risk factors Susceptibility DNA polymorphism Genetic association biology.protein Risk factor General & internal medicine business Controlled study |
| Zdroj: | Medical Principles and Practice |
| ISSN: | 1423-0151 1011-7571 |
| DOI: | 10.1159/000442165 |
| Popis: | Objective: To determine the role of glutathione S-transferase (GST) isoenzyme polymorphisms as susceptibility factors in patients with psoriasis in a Turkish cohort. Subjects and Methods: In this case-control study, 105 patients with plaque-type psoriasis and 102 healthy controls were recruited from the dermatology outpatient clinics of two university hospitals. Genomic DNA was extracted from whole blood using a DZ DNA isolation kit. Multiplex PCR was used to determine GSTM1 and GSTT1 polymorphisms in the isolated DNAs. Results: Of the 150 patients with psoriasis, 83 (79%) were identified with the GSTT1 genotype and 22 (21%) with the null genotype. Of the 102 patients in the control group, 69 (67.6%) subjects were identified with the GSTT1 genotype and 33 (32.4%) with the null genotype. There was no significant difference between the patient and control groups (p = 0.063). Regarding the GSTM1 polymorphism, 54 (51.4%) patients were identified with this genotype and 51 (48.6%) with the null genotype; in the control group, 50 (49%) were identified with this genotype and 52 (51%) with the null genotype. Again there was no statistically significant difference between the groups (p = 0.957). Conclusion: In this Turkish cohort of patients with psoriasis, neither GSTT1 nor GSTM1 polymorphisms were associated with disease susceptibility. Larger studies with a wider range of GST isoenzyme are needed. |
| Databáze: | OpenAIRE |
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