Modulation of cisplatin cytotoxicity by human recombinant interferon-γ in human ovarian cancer cell lines
| Autor: | Pierre Canal, S. Jozan, Christine Chevreau, A. Nehme, Anne Marie Julia, Roland Bugat |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Cancer Research
medicine.medical_specialty Cell Survival medicine.medical_treatment Biology Interferon-gamma Internal medicine Tumor Cells Cultured medicine Humans Cytotoxic T cell Interferon gamma Cytotoxicity Platinum Ovarian Neoplasms Cisplatin Dose-Response Relationship Drug Drug Synergism Immunotherapy medicine.disease Recombinant Proteins In vitro Endocrinology Oncology Cell culture Cancer research Female Drug Screening Assays Antitumor Ovarian cancer medicine.drug |
| Zdroj: | European Journal of Cancer. 30:520-525 |
| ISSN: | 0959-8049 |
| Popis: | Cytotoxic interactions between recombinant human interferon-gamma (IFN gamma) and cisplatin have been studied in six ovarian cell lines (IGROV1, NIHOVCAR3, SKOV3, OVCCR1, 2008 and its cisplatin resident variant 2008/C13*). Studies were performed using a cell survival assay. Results were assessed using median effect analysis. Synergy between these two drugs was observed in cell lines sensitive to IFN gamma, whatever their relative sensitivity or resistance to cisplatin, suggesting that IFN gamma enhances the cytotoxic activity of cisplatin. This interaction is not due to an increase in platinum accumulation in cells. This combination of drugs should be evaluated against human ovarian cancer xenografts in nude mice before its use in clinical practice. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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