Convergent dendrimer synthesis by olefin metathesis and studies toward glycoconjugation
| Autor: | Roberto Guizzardi, Mattia Vacchini, Laura Cipolla, Carlo Santambrogio |
|---|---|
| Přispěvatelé: | Guizzardi, R, Vacchini, M, Santambrogio, C, Cipolla, L |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Olefin metathesis
010405 organic chemistry Chemistry dendrimers glycodendrimers olefin metathesis alkoxyamino-carbonyl chemistry Organic Chemistry Dispersity General Chemistry 010402 general chemistry Metathesis 01 natural sciences Catalysis 0104 chemical sciences chemistry.chemical_compound Dendrimer Polymer chemistry CHIM/06 - CHIMICA ORGANICA Hydroxymethyl |
| Popis: | The synthesis of novel hyperbranched monodisperse linear dendrimers, based on 2,2-bis-(hydroxymethyl)-propionic acid (bis-MPA), has been achieved by convergent metathesis-mediated coupling between the alkene-terminated focal point of bis-MPA dendrons. On their surface, dendrimers present 4, 8 and 16 functional groups. Glycodendrimers exposing multiple saccharide moieties have also been obtained. To the best of our knowledge, this is the first example of the use of metathesis for focal point coupling. |
| Databáze: | OpenAIRE |
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