Arterial smooth muscle cell PKD2 (TRPP1) channels control systemic blood pressure

Autor: Charles R. Mackay, Simon Bulley, Qian Wang, Carlos Fernández-Peña, Kirk W. Evanson, Raquibul Hasan, Jonathan H. Jaggar, M. Dennis Leo, Padmapriya Muralidharan, Sarah K. Burris, Korah P. Kuruvilla
Rok vydání: 2018
Předmět:
Zdroj: Web of Science
ISSN: 1530-6860
0892-6638
Popis: Systemic blood pressure is determined, in part, by arterial smooth muscle cells (myocytes). Several Transient Receptor Potential (TRP) channels are proposed to be expressed in arterial myocytes, but it is unclear if these proteins control physiological blood pressure and contribute to hypertension in vivo . We generated the first inducible, smooth muscle-specific knockout for a TRP channel, namely for PKD2 (TRPP1), to investigate arterial myocyte and blood pressure regulation by this protein. Using this model, we show that intravascular pressure and α 1 -receptors activate PKD2 channels in arterial myocytes of different systemic organs. PKD2 channel activation in arterial myocytes leads to an inward Na+ current, membrane depolarization and vasoconstriction. Inducible, smooth muscle cell-specific PKD2 knockout lowers both physiological blood pressure and hypertension and prevents pathological arterial remodeling during hypertension. In summary, we show for the first time that arterial myocyte PKD2 channels control systemic blood pressure and targeting reduces high blood pressure.
Databáze: OpenAIRE
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