Unexpected role of the human cytomegalovirus contribute to essential hypertension in the Kazakh Chinese population of Xinjiang
| Autor: | Yongmin Liu, Hua Zhong, Jing Hui, Feng-Mei Deng, Yuan-yuan Qu, Fang He, Na Tang, Lamei Wang, Zhen Li, Qian Feng |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Human cytomegalovirus Male Cytomegalovirus Blood Pressure 030204 cardiovascular system & hematology Essential hypertension Antibodies Viral Biochemistry Pathogenesis 0302 clinical medicine Enos Renin Ethnicity Research Articles Aged 80 and over biology Methylation Middle Aged 8-Hydroxy-2'-Deoxyguanosine DNA methylation Cytomegalovirus Infections Female medicine.symptom Renin-angiotensin system Research Article Adult China Adolescent Nitric Oxide Synthase Type III Biophysics Inflammation Peptidyl-Dipeptidase A 03 medical and health sciences Renin–angiotensin system medicine Humans Molecular Biology Aged business.industry Progesterone Reductase Tumor Necrosis Factor-alpha Deoxyguanosine Inflammatory response Cell Biology medicine.disease biology.organism_classification 030104 developmental biology Oxidative stress Case-Control Studies Immunology business |
| Zdroj: | Bioscience Reports |
| ISSN: | 1573-4935 |
| Popis: | Human cytomegalovirus (HCMV) infection, chronic inflammation and oxidative stress, the renin–angiotensin system (RAS), endothelial function, and DNA methylation play roles in the pathogenesis of essential hypertension (EH); however, the mechanism by which HCMV predisposes patients to hypertension remain unclear. Our group previously demonstrated an association between EH and HCMV infection in Kazakh Chinese. Here, we investigated the relationship between HCMV infection and other clinicopathological features in 720 Kazakh individuals with or without hypertension (n=360 each; age: 18–80). Multiple linear and logistic regression analyses were used to determine the associations between HCMV infection, clinical characteristics, and EH. Notably, patients with EH, particularly those with HCMV infection, exhibited a marked increase in tumor necrosis factor-α (TNF-α) and 8-hydroxy-2-deoxyguanosine (8-OHDG) levels, but a decrease in endothelial nitric oxide synthase (eNOS) and renin levels. Similarly, elevated TNF-α and 8-OHDG levels were independent predictors of increased HCMV antibody titers, whereas eNOS and renin were negatively correlated with the latter. Moreover, serum angiotensin-converting enzyme (sACE, ACE) methylation was increased, whereas 11-β hydroxysteroid dehydrogenase 2 (HSD11β2; HSD3B2) methylation was decreased in patients with EH who were also infected with HCMV. A positive correlation between HSD3B2 methylation and HCMV IgG titer and blood pressure was additionally observed, whereas angiotensin-converting enzyme (ACE) methylation was inversely correlated with blood pressure. Collectively, these data indicate that HCMV may contribute to EH development in the Kazakh Chinese by increasing TNF-α and 8-OHDG levels, suppressing eNOS and renin, and manipulating HSD3B2 and ACE methylation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|