The Predictive Value of SPECT/CT imaging in colorectal liver metastases response after 90Y-radioembolization
| Autor: | Andrzej Mazurek, Jan Korniluk, Piotr Piasecki, Mirosław Dziuk, Anna Budzyńska, Piotr Zięcina, Jerzy Narloch, Krzysztof Brzozowski |
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| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Physiology Cancer Treatment lcsh:Medicine Single Photon Emission Computed Tomography Single-photon emission computed tomography 030218 nuclear medicine & medical imaging Diagnostic Radiology 0302 clinical medicine Blood Flow Abdomen Medicine and Health Sciences Yttrium Radioisotopes lcsh:Science Tomography Multidisciplinary medicine.diagnostic_test Phantoms Imaging Pharmaceutics Radiology and Imaging Liver Neoplasms food and beverages Middle Aged Predictive value Embolization Therapeutic Body Fluids Blood Oncology 030220 oncology & carcinogenesis Absorbed dose Disease Progression Female Anatomy Colorectal Neoplasms Research Article Adult Single Photon Emission Computed Tomography Computed Tomography Imaging Techniques Neuroimaging Research and Analysis Methods Imaging phantom 03 medical and health sciences Text mining Dose Prediction Methods Region of interest Diagnostic Medicine medicine Humans Radiometry Aged business.industry fungi lcsh:R Biology and Life Sciences Blood flow Computed Axial Tomography Gastrointestinal Imaging lcsh:Q Ct imaging business Nuclear medicine Liver and Spleen Scan Neuroscience |
| Zdroj: | PLoS ONE, Vol 13, Iss 7, p e0200488 (2018) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | The aim of this study was to evaluate a modified method of calculating the 99mTc/90Y tumor-to-normal-liver uptake ratio (mT/N) based on SPECT/CT imaging, for use in predicting the overall response of colorectal liver tumors after radioembolization. A modified phantom-based method of tumor-to-normal-liver ratio calculation was proposed and assessed. In contrast to the traditional method based on data gathered from the whole tumor, gamma counts are collected only from a 2D region of interest delineated in the SPECT/CT section with the longest tumor diameter (as specified in RECIST 1.1). The modified tumor-to-normal-liver ratio (mT/N1) and 90Y predicted tumor absorbed dose (PAD) were obtained based on 99mTc-MAA SPECT/CT, and similarly the modified tumor-to-normal-liver ratio (mT/N2) and 90Y actual tumor absorbed dose (AAD) were calculated after 90Y-SPECT/CT. Tumor response was assessed on follow-up CTs. Using the newly proposed method, a total of 103 liver colorectal metastases in 21 patients who underwent radioembolization (between June 2009 and October 2015) were evaluated in pre-treatment CT scans and 99mTc-MAA-SPECT/CT scans and compared with post-treatment 90Y-SPECT/CT scans and follow-up CT scans. The results showed that the mT/N1 ratio (p = 0.012), PAD (p < 0.001) and AAD (p < 0.001) were predictors of tumor response after radioembolization. The time to progression was significantly lengthened for tumors with mT/N1 higher than 1.7 or PAD higher than 70 Gy. The risk of progression for tumors with mT/N1 lower than 1.7 or PAD below 70 Gy was significantly higher. The mT/N2 ratio had no significant correlation with treatment results. Conclusion The mT/N1 ratio, PAD, and AAD can be used as predictors of tumor response to SIRT treatment, and SPECT/CT imaging can be used for dosimetric assessment of radioembolization. |
| Databáze: | OpenAIRE |
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