Comparative Evaluation of the Severity of Gastric Ulceration by Solid Dispersions and Coprecipitates of Indomethacin
Autor: | Indra K. Reddy, Michael D. Degennaro, Mansoor A. Khan, Anees Abdulquadar Karnachi |
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Rok vydání: | 1997 |
Předmět: |
Male
Drug medicine.medical_specialty medicine.drug_class media_common.quotation_subject Indomethacin Pharmaceutical Science macromolecular substances Gastroenterology Anti-inflammatory Dosage form Rats Sprague-Dawley Indometacin Oral administration Internal medicine medicine Animals Chemical Precipitation Stomach Ulcer media_common Active ingredient business.industry Stomach Anti-Inflammatory Agents Non-Steroidal Rats Surgery medicine.anatomical_structure Liberation business medicine.drug |
Zdroj: | Journal of Drug Targeting. 4:297-301 |
ISSN: | 1029-2330 1061-186X |
Popis: | The ulcerogenic activity of indomethacin was studied in rats following single and chronic doses of indomethacin in the form of pure drug, solid dispersions and coprecipitates. Each formulation was administrated as a suspension in a 2% methylcellulose solution. Gastrointestinal ulceration was assessed, four hours after a single dose and 24 hours following the last dose of a chronic four day dosing regimen, by counting the number of lesions and ulcers present. A rating scale was employed to evaluate the severity index. The coprecipitate formulation produced less severe ulceration than the solid dispersion and pure drug. This suggests that the severity of ulceration than the solid dispersion and pure drug. This suggests that the severity of ulceration may be related to the preparation methodology and drug release kinetics. |
Databáze: | OpenAIRE |
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