Theonellapeptolide IIIe, a New Cyclic Peptolide from the New Zealand Deep Water Sponge, Lamellomorpha strongylata

Autor:	Shangxiao Li, Murray H. G. Munro, John W. Blunt, Eric J. Dumdei, Ward T. Robinson, L. K. Pannell
Rok vydání:	1998
Předmět:	Protein Conformation Stereochemistry Pharmaceutical Science Antineoplastic Agents Spectrometry Mass Fast Atom Bombardment Peptides Cyclic Gas Chromatography-Mass Spectrometry Analytical Chemistry X-Ray Diffraction Drug Discovery Animals Amino Acids Pharmacology chemistry.chemical_classification biology Lamellomorpha strongylata Organic Chemistry Absolute configuration biology.organism_classification Cyclic peptide Porifera Deep water Chiral column chromatography Sponge Complementary and alternative medicine chemistry Molecular Medicine Theonellapeptolide IIIe Lactone New Zealand
Zdroj:	Journal of Natural Products. 61:724-728
ISSN:	1520-6025 0163-3864
DOI:	10.1021/np970417r
Popis:	The structure, stereochemistry, and conformation of theonellapeptolide IIIe (1), a new 36-membered ring cyclic peptolide from the New Zealand deep-water sponge Lamellomorpha strongylata, is described. The sequence of the cytotoxic peptolide was determined through a combination of NMR and MS-MS techniques and confirmed by X-ray crystal structure analysis, which, with chiral HPLC, established the absolute stereochemistry.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3bb40a7dd5206a754cb465e094f0163 https://doi.org/10.1021/np970417r Zobrazit plný text záznamu