A Brief Analysis of Tissue-Resident NK Cells in Pregnancy and Endometrial Diseases: The Importance of Pharmacologic Modulation
| Autor: | Jenny V. Garmendia, Juan B. De Sanctis |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Cell physiology Cell Inflammation NK cells tissue-resident NK cells Endometrium 03 medical and health sciences 0302 clinical medicine Immune system medicine Pregnancy Fetus tolerance business.industry decidual NK cells conventional NK cells medicine.disease 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology Medicine pregnancy medicine.symptom business Hormone |
| Zdroj: | Immuno, Vol 1, Iss 11, Pp 174-193 (2021) |
| ISSN: | 2673-5601 |
| DOI: | 10.3390/immuno1030011 |
| Popis: | NK cells are lymphocytes involved in the innate and adaptative immune response. These cells are located in peripheral blood and tissues with ample functions, from immune vigilant to tolerogenic reactions. In the endometrium, NK cell populations vary depending on age, hormones, and inflammation. When pregnancy occurs, tissue-resident NK cells and conventional NK cells are recruited to protect the fetus, a tolerogenic response. On the contrary, in the inflamed endometrium, various inflammatory cells down-regulate NK tolerance and impair embryo implantation. Therefore, NK cells’ pharmacological modulation is difficult to achieve. Several strategies have been used, from progesterone, lipid emulsions to steroids; the success has not been as expected. However, new therapeutic approaches have been proposed to decrease the endometrial inflammatory burden and increase pregnancy success based on understanding NK cell physiology. |
| Databáze: | OpenAIRE |
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