Dynamics in the Cytoadherence Phenotypes of Plasmodium falciparum Infected Erythrocytes Isolated during Pregnancy
| Autor: | Nicaise Tuikue Ndam, Achille Massougbodji, Sylvain Sossou-tchatcha, Philippe Deloron, Gilles Cottrell, Justin Doritchamou, Christophe Hounton Houngbeme, Azizath Moussiliou |
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| Přispěvatelé: | Mère et enfant en milieu tropical : pathogènes, système de santé et transition épidémiologique (MERIT - UMR_D 216), Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5), Université d’Abomey-Calavi = University of Abomey Calavi (UAC), Université Paris Descartes - Faculté de Pharmacie de Paris (UPD5 Pharmacie), Université Paris Descartes - Paris 5 (UPD5), Physiologie, physiopathologie et thérapeutique (ED 394), Université Pierre et Marie Curie - Paris 6 (UPMC), Hôpital de zone Suru Léré, Cotonou, Mère et enfant face aux infections tropicales (MERIT - UMR_D 216), University of Abomey Calavi (UAC), Mère et enfant face aux infections tropicales ( MERIT - UMR_D 216 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut de Recherche pour le Développement ( IRD ), University of Abomey Calavi ( UAC ), Université Paris Descartes - Faculté de Pharmacie de Paris ( UPD5 Pharmacie ), Université Paris Descartes - Paris 5 ( UPD5 ), Physiologie, physiopathologie et thérapeutique ( ED 394 ), Université Pierre et Marie Curie - Paris 6 ( UPMC ), Faculté de Pharmacie de Paris - Université Paris Descartes (UPD5 Pharmacie) |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
CD36 Antigens
Erythrocytes Time Factors Transcription Genetic Placenta Protozoan Proteins lcsh:Medicine Cell Separation 0302 clinical medicine Pregnancy Medicine and Health Sciences lcsh:Science 0303 health sciences Multidisciplinary biology Chondroitin Sulfates Pregnancy Outcome Intercellular Adhesion Molecule-1 Acquired immune system 3. Good health Parity Infectious Diseases Phenotype medicine.anatomical_structure Female Research Article Adult Immunology Plasmodium falciparum 030231 tropical medicine Antigens Protozoan Gestational Age Receptors Cell Surface Young Adult 03 medical and health sciences Antigen Immunity [ SDV.MHEP ] Life Sciences [q-bio]/Human health and pathology parasitic diseases Cell Adhesion medicine Humans Cell adhesion Molecular Biology 030304 developmental biology lcsh:R Biology and Life Sciences Cell Biology Tropical Diseases medicine.disease biology.organism_classification Virology Gene Expression Regulation Women's Health Parasitology lcsh:Q Malaria [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology |
| Zdroj: | PLoS ONE PLoS ONE, Public Library of Science, 2014, 9 (6), pp.e98577. ⟨10.1371/journal.pone.0098577⟩ PLoS ONE, Vol 9, Iss 6, p e98577 (2014) PLoS ONE, Public Library of Science, 2014, 9 (6), pp.e98577. 〈10.1371/journal.pone.0098577〉 PLoS ONE, 2014, 9 (6), pp.e98577. ⟨10.1371/journal.pone.0098577⟩ |
| ISSN: | 1932-6203 |
| Popis: | International audience; Pregnant women become susceptible to malaria infection despite their acquired immunity to this disease from childhood. The placental sequestration of Plasmodium falciparum infected erythrocytes (IE) is the major feature of malaria during pregnancy, due to ability of these parasites to bind chondroitin sulfate A (CSA) in the placenta through the VAR2CSA protein that parasites express on the surface of IE. We collected parasites at different times of pregnancy and investigated the adhesion pattern of freshly collected isolates on the three well described host receptors (CSPG, CD36 and ICAM-1). Var genes transcription profile and VAR2CSA surface-expression were assessed in these isolates. Although adhesion of IE to CD36 and ICAM-1 was observed in some isolates, CSA-adhesion was the predominant binding feature in all isolates analyzed. Coexistence in the peripheral blood of several adhesion phenotypes in early pregnancy isolates was observed, a diversity that gradually tightens with gestational age in favour of the CSA-adhesion phenotype. Infections occurring in primigravidae were often by parasites that adhered more to CSA than those from multigravidae. Data from this study further emphasize the specificity of CSA adhesion and VAR2CSA expression by parasites responsible for pregnancy malaria, while drawing attention to the phenotypic complexity of infections occurring early in pregnancy as well as in multigravidae. |
| Databáze: | OpenAIRE |
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