Versatile access to C-4-substituted 2-amino-1,3-azoles from hydropyridines in oxidative conditions
| Autor: | Maria del Rayo Sanchez Salvatori, Ali Al-Mourabit, Marie-Thérèse Martin, Robert Abou-Jneid, Said Ghoulami, Anne Zaparucha |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Azoles
Models Molecular Magnetic Resonance Spectroscopy Molecular Structure Pyridines Organic Chemistry Regioselectivity chemistry.chemical_element General Medicine Oxidative phosphorylation Cleavage (embryo) Nitrogen Combinatorial chemistry chemistry.chemical_compound Kinetics chemistry Urea Aminal Organic chemistry Amine gas treating Amines Guanidine Oxidation-Reduction Electronic properties |
| Zdroj: | The Journal of organic chemistry. 70(20) |
| ISSN: | 0022-3263 |
| Popis: | [Chemical reaction: see text] Various substituted 2-aminotetrahydroazolopyridines and 2-aminohexahydroazolopyridines have been prepared by bromine-mediated addition of protected guanidine or urea to hydropyridine derivatives. The pH-dependent regioselective cleavage of the resulting aminal function led to the 2-aminoazole products III. The yields of the bicycles of type II, and their conversion into azoles III depends on the electronic properties of the substituents on the nitrogen of the tetrahydopyridine. |
| Databáze: | OpenAIRE |
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