Defectivity of Rauscher Murine Erythroblastosis Virus
| Autor: | P. Bentvelzen, A. M. Aarssen, J. Brinkhof |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
Male
Virus Cultivation viruses Spleen Virus Replication Rauscher Virus Urethane General Biochemistry Genetics and Molecular Biology Virus BALB/c Mice Erythroblast medicine Animals Neoplasm Mice Inbred BALB C Leukemia biology Nucleated red cells Defective Viruses General Medicine biology.organism_classification medicine.disease Virology Leukemia Virus Murine Rickettsia medicine.anatomical_structure AKR murine leukemia virus Female Helper Viruses |
| Zdroj: | Nature New Biology. 239:122-123 |
| ISSN: | 2058-1092 0090-0028 |
| DOI: | 10.1038/newbio239122a0 |
| Popis: | THE Rauscher leukaemia virus (RLV) induces a rapidly developing fatal erythroblastosis in mice, characterized by splenomegaly and a highly increased number of nucleated red cells in the peripheral blood1. The first sign of action of the virus is the production of erythroblast foci in the spleen within a week2. A linear dose-response relationship for virus and number of foci has been observed in several mouse strains, suggesting that a colony can be initiated by a single infective unit2. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink