Urinary ATP may be a biomarker for bladder outlet obstruction and its severity in patients with benign prostatic hyperplasia
| Autor: | Xiulin Zhang, Benkang Shi, Shulu Zu, Yaxiao Liu, Yan Li, Mengmeng Zhao, Zhenghao Chen, Shaoyong Wang |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
business.industry Urology Urinary system 030232 urology & nephrology Urine Hyperplasia urologic and male genital diseases medicine.disease Asymptomatic 03 medical and health sciences Bladder outlet obstruction 0302 clinical medicine Reproductive Medicine Lower urinary tract symptoms 030220 oncology & carcinogenesis Medicine Biomarker (medicine) Original Article Benign prostatic hyperplasia (BPH) medicine.symptom business |
| Zdroj: | Transl Androl Urol |
| ISSN: | 2223-4691 2223-4683 |
| Popis: | BACKGROUND: Urothelial cells release ATP into the urine in response to bladder stretch. Urinary ATP concentration in benign prostatic hyperplasia (BPH) patients was higher compared with asymptomatic controls. In this study, we aimed to explore the possibility that the urinary ATP level could be a non-invasive biomarker for bladder outlet obstruction (BOO) and its severity in BPH patients. METHODS: We included 117 BPH patients who underwent urodynamic studies and 109 asymptomatic controls. Urine samples at normal desire (from patients and controls), instilled fluids at maximum cystometric capacity (capacity fluid), and voided fluids during a pressure-flow study (only from patients) were collected. The ATP concentration in collected samples was measured using a luciferin-luciferase bioluminescence assay and normalized to urine creatinine (ATP/Cr). The degree of BOO was quantified using the BOO index (BOOI). Correlation between urodynamic parameters and urinary ATP concentration was analyzed in BPH patients. RESULTS: Urinary ATP concentration of BPH patients was significantly higher compared with controls (P40 was set as a cutoff point to differentiate BOO from non-BOO patients, the area under the receiver operating characteristic (ROC) curve was 0.77 (P |
| Databáze: | OpenAIRE |
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