Flavonoids and triterpenes from Combretum fragrans with anti-inflammatory, antioxidant and antidiabetic potential
| Autor: | Almas Jabeen, Marius Mbiantcha, Fawai Yakai, Amadou Dawe, Mehreen Lateef, Muhammad Ali, Bonaventure T. Ngadjui |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult Antioxidant medicine.drug_class DPPH medicine.medical_treatment Anti-Inflammatory Agents 01 natural sciences General Biochemistry Genetics and Molecular Biology Anti-inflammatory Cirsilineol Antioxidants law.invention Terpene 03 medical and health sciences chemistry.chemical_compound Mice law medicine Animals Humans Hypoglycemic Agents Chemiluminescence chemistry.chemical_classification Flavonoids Reactive oxygen species Traditional medicine Molecular Structure 010405 organic chemistry Plant Extracts alpha-Glucosidases Velutin Triterpenes 0104 chemical sciences Plant Leaves 030104 developmental biology chemistry Combretum Reactive Oxygen Species |
| Zdroj: | Zeitschrift fur Naturforschung. C, Journal of biosciences. 73(5-6) |
| ISSN: | 0939-5075 |
| Popis: | Despite the well-documented benefits of Combretum fragrans in Cameroon, only few scientific works have been done on it. In this study we isolated eight compounds from the leaves extract of C. fragrans: velutin (1), belamcanidin (2), cirsilineol (3), cirsimaritin (4), 3β-acetoxy-20,24-epoxy-11,25-hydroxy-dammarane (5), combretin A (6), combretin B (7) and a mixture of arjunolic acid (8a) and asiatic acid (8b). Compounds 6 and 7 presented potent anti-inflammatory, antioxidant and antidiabetic activities. Compounds 1, 3, 5 and the mixture of 8a and 8b were significantly active, and compounds 2 and 4 presented moderate activity for reactive oxygen species inhibitory and free-radical scavenging. All compounds were isolated using chromatographic techniques; their structures were elucidated by spectroscopic techniques and their spectroscopic data compared with those of the literature. Anti-inflammatory activity was evaluated via the oxidative burst assay using a luminol-amplified chemiluminescence technique, antioxidant activity by free-radical scavenging activity (DPPH) and antidiabetic activity via α-glucosidase inhibition. All of the isolated compounds (1–8) were reported to exhibit significant antioxidant activity. Compounds 1, 3, and 5–8 exhibited potent chemiluminescence inhibition effect, and only compounds 6 and 7 inhibited α-glucosidase. Thus, C. fragrans can be used as an effective natural source of anti-inflammatory, antioxidant and antidiabetic compounds. |
| Databáze: | OpenAIRE |
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