Quantitative lymph node burden as a ‘very-high-risk’ factor identifying head and neck cancer patients benefiting from postoperative chemoradiation
| Autor: | Stephen L. Shiao, Michael Luu, D.J. Lu, Kevin Scher, Sungjin Kim, Alain C. Mita, Allen S. Ho, Mourad Tighiouart, J. Mallen-St. Clair, Zachary S. Zumsteg |
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| Rok vydání: | 2019 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty medicine.medical_treatment Extranodal Disease 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Postoperative Period Lymph node Survival rate Aged Retrospective Studies Squamous Cell Carcinoma of Head and Neck business.industry Head and neck cancer Margins of Excision Retrospective cohort study Neck dissection Original Articles Chemoradiotherapy Adjuvant Hematology Middle Aged Prognosis medicine.disease Combined Modality Therapy Corrigenda Head and neck squamous-cell carcinoma Survival Rate 030104 developmental biology medicine.anatomical_structure Head and Neck Neoplasms 030220 oncology & carcinogenesis Female Lymph Nodes business Chemoradiotherapy Follow-Up Studies |
| Zdroj: | Annals of Oncology. 30:76-84 |
| ISSN: | 0923-7534 |
| DOI: | 10.1093/annonc/mdy490 |
| Popis: | BACKGROUND: Adjuvant chemoradiation (CRT) is standard for head and neck squamous cell carcinoma (HNSCC) patients with positive margins or extranodal extension (ENE) following surgery. However, emerging evidence suggests the number of positive lymph nodes (LNs) is the dominant determinant of survival in non-oropharyngeal HNSCC and thus may better identify those benefiting from treatment intensification. PATIENTS AND METHODS: Patients from the National Cancer Database diagnosed with non-oropharyngeal HNSCC (oral cavity, larynx, hypopharynx) between 2004 and 2014 and undergoing surgical resection, neck dissection, and postoperative radiotherapy (RT) were included. Multivariable regression with first-order interaction terms was used to model the interaction between postoperative CRT and continuous number of positive LNs with respect to overall survival. RESULTS: In total, 7144 patients met inclusion criteria. In multivariable analysis, increasing number of positive LNs was associated with both increasing mortality (P |
| Databáze: | OpenAIRE |
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