Role of Plasma Membrane Calcium ATPases in Calcium Clearance from Olfactory Sensory Neurons
| Autor: | Judith Van Houten, Megan S. Valentine, S. Ponissery Saidu, S.D. Weeraratne, Rona J. Delay |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Indoles
Physiology Calcium pump chemistry.chemical_element Calcium Biology Olfactory Receptor Neurons Sodium-Calcium Exchanger Gene Knockout Techniques Mice Plasma Membrane Calcium-Transporting ATPases Behavioral Neuroscience Physiology (medical) medicine Animals Protein Isoforms Enzyme Inhibitors Cells Cultured Mice Knockout Sodium-calcium exchanger Cell Membrane Colforsin Sodium Articles Dendritic knob Sensory Systems Sensory neuron Cell biology Mice Inbred C57BL Kinetics medicine.anatomical_structure chemistry Biochemistry Plasma membrane Ca2+ ATPase Transduction (physiology) |
| Zdroj: | Chemical Senses. 34:349-358 |
| ISSN: | 1464-3553 0379-864X |
| DOI: | 10.1093/chemse/bjp008 |
| Popis: | Odorants cause Ca(2+) to rise in olfactory sensory neurons (OSNs) first within the ciliary compartment, then in the dendritic knob, and finally in the cell body. Ca(2+) not only excites but also produces negative feedback on the transduction pathway. To relieve this Ca(2+)-dependent adaptation, Ca(2+) must be cleared from the cilia and dendritic knob by mechanisms that are not well understood. This work focuses on the roles of plasma membrane calcium pumps (PMCAs) through the use of inhibitors and mice missing 1 of the 4 PMCA isoforms (PMCA2). We demonstrate a significant contribution of PMCAs in addition to contributions of the Na(+)/Ca(2+) exchanger and endoplasmic reticulum (ER) calcium pump to the rate of calcium clearance after OSN stimulation. PMCAs in neurons can shape the Ca(2+) signal. We discuss the contributions of the specific PMCA isoforms to the shape of the Ca(2+) transient that controls signaling and adaptation in OSNs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|