Understanding the Molecular and Cell Biological Mechanisms of Electrical Synapse Formation
Autor: | Abagael M Lasseigne, E. Anne Martin, Adam C. Miller |
---|---|
Rok vydání: | 2020 |
Předmět: |
electrical synapse
0301 basic medicine connexin Neuroscience (miscellaneous) Synaptogenesis Connexin Review Biology lcsh:RC321-571 lcsh:QM1-695 Adherens junction 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine cell biology medicine junction Electrical synapse lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry Zebrafish synaptogenesis Tight junction Gap junction cytoskeleton lcsh:Human anatomy zebrafish biology.organism_classification 030104 developmental biology medicine.anatomical_structure Electrical Synapses Cx36 Anatomy Neuroscience 030217 neurology & neurosurgery |
Zdroj: | Frontiers in Neuroanatomy Frontiers in Neuroanatomy, Vol 14 (2020) |
ISSN: | 1662-5129 |
Popis: | In this review article, we will describe the recent advances made towards understanding the molecular and cell biological mechanisms of electrical synapse formation. New evidence indicates that electrical synapses, which are gap junctions between neurons, can have complex molecular compositions including protein asymmetries across joined cells, diverse morphological arrangements, and overlooked similarities with other junctions, all of which indicate new potential roles in neurodevelopmental disease. Aquatic organisms, and in particular the vertebrate zebrafish, have proven to be excellent models for elucidating the molecular mechanisms of electrical synapse formation. Zebrafish will serve as our main exemplar throughout this review and will be compared with other model organisms. We highlight the known cell biological processes that build neuronal gap junctions and compare these with the assemblies of adherens junctions, tight junctions, non-neuronal gap junctions, and chemical synapses to explore the unknown frontiers remaining in our understanding of the critical and ubiquitous electrical synapse. |
Databáze: | OpenAIRE |
Externí odkaz: |