High-pressure liquid chromatographic determination of viloxazine in human plasma and urine

Autor:	Roberta Gillilan, William D. Masonx
Rok vydání:	1981
Předmět:	Chromatography Bioavailability Study Chemistry Morpholines Extraction (chemistry) Pharmaceutical Science Urine Viloxazine Kinetics Human plasma High pressure medicine Humans Chromatography High Pressure Liquid medicine.drug
Zdroj:	Journal of pharmaceutical sciences. 70(2)
ISSN:	0022-3549
Popis:	A rapid, specific, high-pressure liquid chromatographic method is presented for the determination of viloxazine in plasma and urine. This method employs the high sensitivity of fluorescence detection with selective extraction and reversed-phase chromatography to measure concentrations as low as 25 ng/ml of plasma and 1.0 μg/ml of urine. Known metabolites of viloxazine do not interfere with the analysis, and experience with several hundred samples in a bioavailability study demonstrated the applicability and reliability of the method.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3ae6384ede735d18766545d188e16ef https://pubmed.ncbi.nlm.nih.gov/7205231 Zobrazit plný text záznamu Plný text