Prognostic significance of lymphopenia in sarcoidosis
| Autor: | Olof Selroos, Elli Koivunen |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
Adult
Male medicine.medical_specialty Sarcoidosis Lymphocyte Disease Granulocyte Gastroenterology Leukocyte Count Internal medicine Lymphopenia Internal Medicine Medicine Humans In patient Aged Erythema nodosum business.industry Monocyte Middle Aged medicine.disease Prognosis medicine.anatomical_structure Immunology Chronic Disease Female Good prognosis business Follow-Up Studies |
| Zdroj: | Acta medica Scandinavica. 206(4) |
| ISSN: | 0001-6101 |
| Popis: | During 1959--67, sarcoidosis were diagnosed in a series of 140 patients. All were followed up and 22 developed chronic sarcoidosis. In 134 patients (20 with chronic course) the initial granulocyte, monocyte and lymphocyte counts were known. No differences in granulocyte values were seen between different groups of sarcoidosis patients. Patients with erythema nodosum had significantly increased monocyte levels. Lymphopenia below 1 000/microliter was seen in only 7.5% of the patients. Lymphocyte counts below 1 500 microliter were a common finding, especially in patients developing chronic sarcoidosis. Significantly decreased lymphocyte values were also seen in patients older than 40 years at the time of diagnosis, in patients negative to 10 TU of PPD and in those with a disease requiring treatment with corticosteroids. A correlation was found between initial lymphopenia and less favourable prognosis, 85% of the patients having a very good prognosis. Patients with initial lymphopenia must be carefully followed up. The initial presence of erythema nodosum does not always guarantee a good prognosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text