Carotid Arterial Calcium Scoring Using Upper Airway Computed Tomography in Patients with Obstructive Sleep Apnea: Efficacy as a Clinical Predictor of Cerebrocardiovascular Disease
| Autor: | J.-H. Choi, Kyoo Sang Jo, Eun Ju Kang, Chul-Hoon Kim, Tae Kyung Koh, Sang Joon Kim, Jong Kuk Kim, Moon Sung Kim, Woo Yong Bae, Jae Hoon Lee |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male medicine.medical_specialty Multivariate analysis Polysomnography Severity of Illness Index 030218 nuclear medicine & medical imaging Calcification 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Medicine Humans Radiology Nuclear Medicine and imaging Risk factor Cardiovascular Imaging Computed tomography Aged Aged 80 and over Univariate analysis Sleep Apnea Obstructive medicine.diagnostic_test business.industry Incidence (epidemiology) Brain Middle Aged medicine.disease Obstructive sleep apnea respiratory tract diseases Arterial calcification Airway Cerebrovascular Disorders Carotid Arteries 030220 oncology & carcinogenesis Multivariate Analysis Cardiology Original Article Calcium Female business Tomography X-Ray Computed Carotid artery |
| Zdroj: | Korean Journal of Radiology |
| ISSN: | 2005-8330 1229-6929 |
| Popis: | Objective To evaluate the value of airway computed tomography (CT) in patients with obstructive sleep apnea (OSA) as a predictor of cerebrocardiovascular disease (CCVD) clinically, by quantitatively analyzing carotid arterial calcification (CarAC). Materials and methods This study included 287 patients aged 40-80 years, who had undergone both polysomnography (PSG) and airway CT between March 2011 and October 2015. The carotid arterial calcium score (CarACS) was quantified using the modified Agatston method on each upper airway CT. The OSA severity was categorized as normal, mild, moderate, and severe using the PSG results. Clinical characteristics, comorbid diseases, and lipid profiles of all patients were analyzed, and the prevalence of CCVDs was investigated during the follow up period (52.2 ± 16.0 months). Results CCVD occurred in 27 patients (9.3%) at the end of follow-up, and the CCVD-present groups showed a significantly older mean age (57.5 years vs. 54.2 years), higher prevalence of hypertension (59% vs. 34%) and CarAC (51.9% vs. 20.8%), whereas sex, other comorbid diseases, and severity of OSA were not significantly different from the CCVD-absent group. A univariate analysis showed that age, hypertension, incidence of CarAC, and CarACS were risk factors for the occurrence of CCVD events. In a multivariate analysis, the incidence of CarAC was the only independent risk factor for CCVD. Conclusion CarAC is an independent risk factor for CCVD, whereas the severity of OSA is not a contributory risk factor in patients with OSA. Therefore, additional analysis of CarACS based on airway CT scans may be useful for predicting CCVD. |
| Databáze: | OpenAIRE |
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