Neural Activation during Anticipated Peer Evaluation and Laboratory Meal Intake in Overweight Girls with and without Loss of Control Eating
| Autor: | Sara E. Field, Eric E. Nelson, Daniel S. Pine, Lauren B. Shomaker, Marian Tanofsky-Kraff, Sheila M. Brady, Amber B. Courville, Jack A. Yanovski, Adrienne L. Romer, Louise Hannallah, Scott G. Engel, Johanna M. Jarcho, Andrew P. Demidowich, Anna Vannucci |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Adolescent
Cognitive Neuroscience Ventromedial prefrontal cortex Overweight Article Developmental psychology Eating medicine Humans Obesity Peer Influence Overeating Prefrontal cortex Child medicine.diagnostic_test Peer feedback digestive oral and skin physiology Brain Distress medicine.anatomical_structure Neurology Anxiety Female medicine.symptom Nerve Net Functional magnetic resonance imaging Psychology |
| Popis: | The interpersonal model of loss of control (LOC) eating proposes that socially distressing situations lead to anxious states that trigger excessive food consumption. Self-reports support these links, but the neurobiological underpinnings of these relationships remain unclear. We therefore examined brain regions associated with anxiety in relation to LOC eating and energy intake in the laboratory. Twenty-two overweight and obese (BMIz: 1.9 ± 0.4) adolescent (15.8 ± 1.6 y) girls with LOC eating (LOC +, n = 10) and without LOC eating (LOC −, n = 12) underwent functional magnetic resonance imaging (fMRI) during a simulated peer interaction chatroom paradigm. Immediately after the fMRI scan, girls consumed lunch ad libitum from a 10,934-kcal laboratory buffet meal with the instruction to “let yourself go and eat as much as you want.” Pre-specified hypotheses regarding activation of five regions of interest were tested. Analysis of fMRI data revealed a significant group by peer feedback interaction in the ventromedial prefrontal cortex (vmPFC), such that LOC + had less activity following peer rejection (vs. acceptance), while LOC − had increased activity (p |
| Databáze: | OpenAIRE |
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