Predicting Therapeutic Efficacy of Vascular Disrupting Agent CA4P in Rats with Liver Tumors by Hepatobiliary Contrast Agent Mn-DPDP-Enhanced MRI
| Autor: | Yewei Liu, Shuncong Wang, Yue Li, Gang Huang, Guy Bormans, Yicheng Ni, Feng Chen, Qiu Guan, Raymond Oyen, Jianjun Liu, Jie Yu, Shaoli Song, Jos van Pelt, Frederik De Keyzer, Xiangyong Kong, Johan F.M. Swinnen, Yuanbo Feng |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Original article Cancer Research Pathology medicine.medical_specialty Necrosis MODELS MULTICENTER lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine In vivo HEPATOCELLULAR-CARCINOMA Medicine Science & Technology LESIONS medicine.diagnostic_test business.industry MNDPDP MICROANGIOGRAPHY Combretastatin A4 phosphate Magnetic resonance imaging HCCS lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens 030104 developmental biology Oncology Microangiography 030220 oncology & carcinogenesis GD-EOB-DTPA Histopathology medicine.symptom business Life Sciences & Biomedicine GADOTERATE MEGLUMINE |
| Zdroj: | Translational Oncology, Vol 13, Iss 1, Pp 92-101 (2020) Translational Oncology |
| ISSN: | 1936-5233 |
| DOI: | 10.1016/j.tranon.2019.09.010 |
| Popis: | To evaluate hepatobiliary-specific contrast agent (CA) mangafodipir trisodium (Mn-DPDP)-enhanced magnetic resonance imaging (MRI) for predicting the therapeutic efficacy of the vascular disrupting agent combretastatin A4 phosphate (CA4P) in rats with primary and secondary liver tumors, 36 primary hepatocellular carcinomas (HCCs) were raised by diethylnitrosamine gavage in 16 male rats, in 6 of which one rhabdomyosarcomas (R1) was intrahepatically implanted as secondary liver tumors. On a 3.0T MR scanner with a wrist coil, tumors were monitored weekly by T2-/T1-weighted images (T2WI/T1WI) and characterized by Mn-DPDP-enhanced MRI. CA4P-induced intratumoral necrosis was depicted by nonspecific gadoterate meglumine (Gd-DOTA)-enhanced MRI before and 12 h after therapy. Changes of tumor-to-liver contrast (ΔT/L) on Mn-DPDP-enhanced images were analyzed. In vivo MRI findings were verified by postmortem microangiography and histopathology. Rat models of primary HCCs in a full spectrum of differentiation and secondary R1 liver tumors were successfully generated. Mn-DPDP-enhanced ΔT/L was negatively correlated with HCC differentiation grade (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|