Synthesis, characterization and photodynamic activity of half-sandwich rhodium(III) complexes with curcuminoids
| Autor: | Baoqu Zhang, Peiyuan Li, Xiaohui Wang, Wei Su, Jun’an Xiao |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Confocal
medicine.medical_treatment Biophysics Cancer therapy chemistry.chemical_element Antineoplastic Agents Photodynamic therapy Dermatology Crystallography X-Ray Iridium Rhodium HeLa chemistry.chemical_compound Diarylheptanoids Ic50 values medicine Humans Pharmacology (medical) Curcuminoid Photosensitizing Agents biology Chemistry biology.organism_classification Fluorescence Combinatorial chemistry Photochemotherapy Oncology |
| Zdroj: | Photodiagnosis and Photodynamic Therapy. 32:102049 |
| ISSN: | 1572-1000 |
| DOI: | 10.1016/j.pdpdt.2020.102049 |
| Popis: | Half-sandwich Cp*-Rh complexes containing curcuminoids ([Rh(η5-Cp*)(L)(Py)]PF6, 1–3, L = curcuminoid ligands L1–L3) were prepared, characterized and studied for anticancer activity. Complex 1 was structurally characterized by single-crystal X-ray crystallography. Complex 3 presented excellent photodynamic anticancer effect in light (>400 nm) showing IC50 values of 7.5 and 4.3 μM against HepG2, SKOV3 and HeLa, respectively, along with the 12.4, 7.9 and 4.7-fold lower toxicity in the dark. Confocal fluorescence images show that the complex primarily targeted mitochondrial localization. These results suggest that the complex 3 was a valuable agent with higher efficacy for chemotherapy and photodynamic therapy, which can achieve real-time image guidance in cancer therapy for the fluorescence of the complex as imaging signals. This investigation provides a valuable route to design novel half-sandwich Cp*-Rh complexes with higher efficacy for photodynamic anticancer chemotherapy. |
| Databáze: | OpenAIRE |
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