Medial prefrontal cortex (A32 and A25) projections in the common marmoset: a subcortical anterograde study
Autor: | Paulo Leonardo Araújo de Góis Morais, Ruthnaldo Rodrigues Melo de Lima, Jeferson S. Cavalcante, Helder Henrique Alves de Medeiros, Jorge Alexander Ríos-Flórez, Expedito Silva do Nascimento Júnior |
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Rok vydání: | 2020 |
Předmět: |
Male
Nervous system Science Thalamus Hypothalamus Biotin Prefrontal Cortex Article Stereotaxic Techniques 03 medical and health sciences Diencephalon 0302 clinical medicine Gyrus biology.animal Cortex (anatomy) Neural Pathways medicine Epithalamus Animals Prefrontal cortex 030304 developmental biology 0303 health sciences Biotinylated dextran amine Brain Mapping Multidisciplinary biology Immunochemistry Biological techniques Marmoset Brain Callithrix Dextrans Cognitive neuroscience Amygdala medicine.anatomical_structure nervous system Central nervous system Medicine Female Structural biology Neuroscience 030217 neurology & neurosurgery |
Zdroj: | Scientific Reports Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021) |
ISSN: | 2045-2322 |
Popis: | This study was aimed at establishing the subcorticals substrates of the cognitive and visceromotor circuits of the A32 and A25 cortices of the medial prefrontal cortex and their projections and interactions with subcortical complexes in the common marmoset monkey (Callithrix jacchus). The study was primarily restricted to the nuclei of the diencephalon and amygdala. The common marmoset is a neotropical primate of the new world, and the absence of telencephalic gyrus favors the mapping of neuronal fibers. The biotinylated dextran amine was employed as an anterograde tracer. There was an evident pattern of rostrocaudal distribution of fibers within the subcortical nuclei, with medial orientation. Considering this distribution, fibers originating from the A25 cortex were found to be more clustered in the diencephalon and amygdala than those originating in the A32 cortex. Most areas of the amygdala received fibers from both cortices. In the diencephalon, all regions received projections from the A32, while the A25 fibers were restricted to the thalamus, hypothalamus, and epithalamus at different densities. Precise deposits of neuronal tracers provided here may significantly contribute to expand our understanding of specific connectivity among the medial prefrontal cortex with limbic regions and diencephalic areas, key elements to the viscerocognitive process. |
Databáze: | OpenAIRE |
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