Gate control of mechanical itch by a subpopulation of spinal cord interneurons
| Autor: | Qiufu Ma, Euiseok J. Kim, Olivier Britz, Antoine Dalet, Anirvan Ghosh, Lidia Garcia-Campmany, Steeve Bourane, Bo Duan, Martyn Goulding, Longzhen Cheng, Stephanie C. Koch |
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| Rok vydání: | 2015 |
| Předmět: |
Mechanotransduction
General Science & Technology Population Action Potentials Mice Transgenic Stimulation Gating Neurotransmission Inhibitory postsynaptic potential Mechanotransduction Cellular Synaptic Transmission Transgenic Mice Interneurons Animals Medicine Neuropeptide Y education Skin education.field_of_study Multidisciplinary business.industry Pruritus Pain Research Neurosciences Neural Inhibition Neuropeptide Y receptor Spinal cord medicine.anatomical_structure Spinal Cord Neurological Cellular Chronic Pain business Mechanoreceptors Neuroscience Hair |
| Zdroj: | Science (New York, N.Y.), vol 350, iss 6260 |
| ISSN: | 1095-9203 0036-8075 |
| DOI: | 10.1126/science.aac8653 |
| Popis: | A circuit controlling mechanical itch Considerable progress has been made in understanding and treating chemically induced itch. However, little is known about the mechanisms underlying mechanically evoked itch. Bourane et al. produced a model of mechanical itch by reducing the number of neuropeptide Y–expressing inhibitory spinal interneurons. This led to a selective increase in mechanically evoked itch-like behavior in mice. In contrast, chemically evoked itch or pain behavior remained unaffected. Science , this issue p. 550 |
| Databáze: | OpenAIRE |
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