Primary Ureteral Thyroid Transcription Factor 1–Positive Small Cell Neuroendocrine Carcinoma
Autor: | Andres M. Acosta, Farid Saei Hamedani, Joshua J. Meeks, Shoujin Wu |
---|---|
Rok vydání: | 2015 |
Předmět: |
Male
Pathology medicine.medical_specialty Urinary system Thyroid Nuclear Factor 1 Small-cell carcinoma Pathology and Forensic Medicine Ureter Biomarkers Tumor medicine Humans Carcinoma Small Cell Aged Upper urinary tract Urinary bladder biology Ureteral Neoplasms business.industry Genitourinary system Nuclear Proteins Chromogranin A medicine.disease Carcinoma Neuroendocrine medicine.anatomical_structure Synaptophysin biology.protein Surgery Anatomy business Transcription Factors |
Zdroj: | International Journal of Surgical Pathology. 23:472-477 |
ISSN: | 1940-2465 1066-8969 |
Popis: | Upper urinary tract neoplasms comprise only 5% of urinary malignancies overall, the overwhelming majority showing an urothelial histology. Nonurothelial lesions represent 1.9% of upper tract neoplasms, and small cell carcinomas (SmCCs) only account for a minute fraction of them, with few cases reported in the literature to date. In the genitourinary tract, these lesions are most frequently found in the urinary bladder, where they tend to show a mixed histology with a characteristic small cell neuroendocrine component that is positive for chromogranin A, synaptophysin, and CD56 immunostains. Urinary SmCCs are almost invariably aggressive, with a propensity to infiltrate surrounding tissues and vascular structures. Unfortunately, clinical stage at presentation is often advanced, with early dissemination to lymph nodes or distant organs in a significant proportion of patients. For the most part, prognosis is dismal and can be predicted by the pathologic stage at diagnosis. Recently, new chemotherapeutic regimens have shown some potential benefit for the treatment of urinary SmCC, albeit not achieving curative results. Here we present the case of a 71-year-old male patient with a history of treated bladder urothelial carcinoma that presented with subacute flank pain and was diagnosed with a primary pure SmCC of the ureter. Besides the usual neuroendocrine immunomarkers, this tumor showed intense positivity for TTF-1 (thyroid transcription factor-1), a phenomenon that has been described for extrapulmonary SmCC of other locations. |
Databáze: | OpenAIRE |
Externí odkaz: |