Dietary supplementation of Ashwagandha (Withania somnifera, Dunal) enhances NK cell function in ovarian tumors in the laying hen model of spontaneous ovarian cancer

Autor:	Sanjib Basu, Sameer Sharma, Pincas Bitterman, Jacques S. Abramowicz, Heather Lopez, Janice M. Bahr, Animesh Barua, Michael J. Bradaric
Rok vydání:	2013
Předmět:	medicine.medical_specialty Stromal cell endocrine system diseases medicine.medical_treatment Immunology Cell Population Biology Withania somnifera Immune system Internal medicine medicine Immunology and Allergy Animals education Poultry Diseases Ovarian Neoplasms Tumor microenvironment education.field_of_study Plant Extracts Obstetrics and Gynecology Immunosuppression medicine.disease biology.organism_classification female genital diseases and pregnancy complications Killer Cells Natural Disease Models Animal Endocrinology medicine.anatomical_structure Reproductive Medicine Dietary Supplements Cancer research Disease Progression Female Ovarian cancer Chickens
Zdroj:	American journal of reproductive immunology (New York, N.Y. : 1989). 70(6)
ISSN:	1600-0897
Popis:	Problem Ovarian cancer (OVCA) disseminates in a distinct pattern through peritoneal metastasis and little is known about the immunosuppression in the tumor microenvironment. Our goal was to determine changes in NK cell population during OVCA development and the effects of Ashwagandha (Withania somnifera, Dunal) supplementation on NK cell localization in laying hens with OVCA. Methods Frequency of NK cells in ovarian tumors at early and late stages in 3- to 4-year-old hens (exploratory study) as well as in hens supplemented with dietary Ashwagandha root powder for 90 days (prospective study) was examined. Results The population of stromal NK cells but not the intratumoral NK cells increased with OVCA development and progression. Ashwagandha supplementation decreased the incidence and progression of OVCA. Both the stromal and intratumoral NK cell population increased significantly (P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3a2eaac14df12b4de0701c8df480d60 https://pubmed.ncbi.nlm.nih.gov/24188693 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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