FR-like EBNA1 binding repeats in the human genome
| Autor: | Maria Werner, Aymeric Fouquier d'Hérouël, Anna Birgersdotter |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Herpesvirus 4
Human Carrier Proteins/genetics Microbiologie [F11] [Sciences du vivant] viruses Autoantigens/genetics Genome Autoantigens Repetitive Sequences Nucleic Acid/genetics/physiology Epstein–Barr virus Family of Repeats Human binding sites Iron-Binding Proteins hemic and lymphatic diseases DNA/metabolism Microbiology [F11] [Life sciences] Genetics education.field_of_study Extracellular Matrix Proteins Nuclear Proteins Epstein-Barr Virus Nuclear Antigens/genetics/metabolism DNA-Binding Proteins Regulatory sequence Proteoglycans Population Genome Viral Herpesvirus 4 Human/genetics/metabolism Biology Eye Proteins/genetics Extracellular Matrix Proteins/genetics Iodide Peroxidase Viral entry Virology otorhinolaryngologic diseases Humans education Eye Proteins Transcription factor Gene Repetitive Sequences Nucleic Acid EBNA1 Binding Sites Genome Human Iron-Binding Proteins/genetics DNA Calmodulin-Binding Proteins/genetics Iodide Peroxidase/genetics Nuclear Proteins/genetics stomatognathic diseases Viral replication Epstein-Barr Virus Nuclear Antigens Proteoglycans/genetics DNA-Binding Proteins/genetics/metabolism Human genome Calmodulin-Binding Proteins Carrier Proteins Transcription Factors |
| Zdroj: | Virology. 405(2):524-529 |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2010.06.040 |
| Popis: | Epstein–Barr virus (EBV) is widely spread in the human population. EBV nuclear antigen 1 (EBNA1) is a transcription factor that activates viral genes and is necessary for viral replication and partitioning, which binds the EBV genome cooperatively. We identify similar EBNA1 repeat binding sites in the human genome using a nearest-neighbor positional weight matrix. Previously experimentally verified EBNA1 sites in the human genome are successfully recovered by our approach. Most importantly, 40 novel regions are identified in the human genome, constituted of tandemly repeated binding sites for EBNA1. Genes located in the vicinity of these regions are presented as possible targets for EBNA1-mediated regulation. Among these, four are discussed in more detail: IQCB1, IMPG1, IRF2BP2 and TPO. Incorporating the cooperative actions of EBNA1 is essential when identifying regulatory regions in the human genome and we believe the findings presented here are highly valuable for the understanding of EBV-induced phenotypic changes. |
| Databáze: | OpenAIRE |
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