Biological properties of volatile oil from Brazilian brown propolis
| Autor: | Antônio Eduardo Miller Crotti, Vitor Hugo Melo de Lima, João Matias de Souza, Karoliny de Cassia Rodrigues Almeida, Cassia Cristina Fernandes Alves, Matheus Leandro Rodrigues, Iara Silva Squarisi, Carlos Henrique Gomes Martins, Arthur Barcelos Ribeiro, Denise Crispim Tavares, Mayker Lazaro Dantas Miranda |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
ABTS
Antioxidant biology 010405 organic chemistry DPPH medicine.medical_treatment lcsh:RS1-441 Propolis biology.organism_classification 01 natural sciences 0104 chemical sciences Apitherapy lcsh:Pharmacy and materia medica 010404 medicinal & biomolecular chemistry chemistry.chemical_compound chemistry medicine Food science General Pharmacology Toxicology and Pharmaceutics Antibacterial activity Aroma Nerolidol |
| Zdroj: | Revista Brasileira de Farmacognosia, Vol 29, Iss 6, Pp 807-810 (2019) |
| Popis: | Propolis, is a bee product collected from exudates and flower buds of several plants, has strong aroma and several biological applications. This study aimed at evaluating the chemical composition and in vitro antioxidant, antibacterial and cytotoxic properties of volatile oil from Brazilian brown propolis. It was extracted by hydrodistillation and analyzed by gas chromatography-flame ionization detection and gas chromatography-mass spectrometry. Volatile oil from brown propolis exhibited strong antibacterial activity against H. pylori (MIC 3.25 μg/ml), Mycobacterium tuberculosis (MIC 50 μg/ml) and M. avium (MIC 62.5 μg/ml). It was evaluated in vitro for antioxidant activity by DPPH (IC50 25.0 μg/ml) and ABTS (IC50 30.1 μg/ml) methods. Its cytotoxic property was evaluated in normal (human fibroblasts, GM07429A) and tumor (MCF-7-human breast adenocarcinoma; HeLa-human cervical adenocarcinoma and M059J-human glioblastoma) cell lines. IC50 values were 81.32 μg/ml for GM07429A and 85.00, 129.40 and 84.12 μg/ml for MCF-7, HeLa and M059J cells, respectively. Three major dereplicated components of volatile oil from brown propolis were acetophenone (15.2%), nerolidol (13.3%), and spathulenol (11.6%). Our results contribute to a better understanding of the chemical and biological properties of Brazilian brown propolis and provide evidence for its potential medicinal use. Keywords: Apis mellifera, Resin, Balsamic substances, Volatiles, Apitherapy |
| Databáze: | OpenAIRE |
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