Familial Glomerulonephropathy in the Bullmastiff
| Autor: | Donna M. Dambach, Paula S. Henthorn, D. F. Patterson, P. F. Jezyk, T. Meister, Margret L. Casal |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Male
0301 basic medicine Pathology medicine.medical_specialty Urinalysis 040301 veterinary sciences biology.animal_breed Genes Recessive Anorexia 0403 veterinary science 03 medical and health sciences chemistry.chemical_compound Lethargy Dogs Bullmastiff Animals Medicine Dog Diseases Creatinine Kidney General Veterinary biology medicine.diagnostic_test Glomerulosclerosis Focal Segmental business.industry Glomerulosclerosis Histology 04 agricultural and veterinary sciences medicine.disease Blood Cell Count Pedigree 030104 developmental biology medicine.anatomical_structure chemistry Female medicine.symptom business |
| Zdroj: | Veterinary Pathology. 41:319-325 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1354/vp.41-4-319 |
| Popis: | Glomerular disease was diagnosed by histopathologic examination in 11 related Bullmastiff dogs, and clinical and laboratory data were collected retrospectively. Four female and seven male dogs between the ages of 2.5 and 11 years were affected. Clinical signs, including lethargy and anorexia, were nonspecific and occurred shortly before death or euthanasia. In five affected dogs serial blood samples were obtained, and dramatically elevated blood urea nitrogen and creatinine levels were demonstrated up to 2.75 years before death. Protein-creatinine ratios were elevated in six of six dogs and were above normal 3.5 years before death in one dog. The kidneys appeared grossly normal to slightly smaller than normal at necropsy. Histologic abnormalities of the kidneys were consistent with chronic glomerulonephropathy with sclerosis. Examination of the pedigrees of related affected dogs yielded evidence supporting an autosomal recessive mode of inheritance. |
| Databáze: | OpenAIRE |
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