Porphyrin dyads linked by a rotatable 3,3'-biphenyl scaffold: a new binding motif for small ditopic molecules
| Autor: | Amy Rachel Mulholland, Pall Thordarson, Emily Jane Mensforth, Steven J. Langford |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Biphenyl
chemistry.chemical_classification Models Molecular Rotation Stereochemistry Chemistry Metalloporphyrins Pyridines Organic Chemistry Biphenyl Compounds Molecular Conformation Free base Cooperative binding Context (language use) Peptide Biochemistry Porphyrin chemistry.chemical_compound Zinc polycyclic compounds Molecule Physical and Theoretical Chemistry Dimerization Stoichiometry |
| Zdroj: | Organicbiomolecular chemistry. 10(30) |
| ISSN: | 1477-0539 |
| Popis: | Synthetic access to a set of metallo- and free base bis-porphyrins has been provided by a stepwise approach involving sequential peptide and Suzuki couplings. Linking these porphyrins through a 3,3′-biphenyl bridge enables cooperative binding to ditopic ligands such as the bipyridyls. Association constants and binding stoichiometry has been determined by spectroscopic/spectrophotometric means and the differences in the binding affinities of a small series of diaza ligands is discussed in the context of structural fit and microscopic association constants. |
| Databáze: | OpenAIRE |
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