Autor: |
D B Wasson, Ellen Lakow, Dennis A. Carson, Naoyuki Kamatani |
Rok vydání: |
2014 |
Předmět: |
|
Zdroj: |
Immunology today. 2(12) |
ISSN: |
0167-5699 |
Popis: |
Two inborn errors of purine metabolism have been associated with autosomally inherited human immunodeficiency diseases. A lack of adenosine deaminase (ADA) produces severe lymphopenia and a combined immunodeficiency syndrome. A deficiency of purine nucleoside phosphorylase (PNP) is associated with a selective cellular immune depth. This article discusses the probable biochemical basis for lymphocyte-specific toxicity in these disorders. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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