Lymphocyte dysfunction caused by deficiencies in purine metabolism

Autor:	D B Wasson, Ellen Lakow, Dennis A. Carson, Naoyuki Kamatani
Rok vydání:	2014
Předmět:	biology Lymphocyte Immunology Human immunodeficiency virus (HIV) Purine nucleoside phosphorylase medicine.disease_cause Adenosine deaminase Immune system medicine.anatomical_structure Toxicity biology.protein medicine Combined immunodeficiency syndrome Purine metabolism
Zdroj:	Immunology today. 2(12)
ISSN:	0167-5699
Popis:	Two inborn errors of purine metabolism have been associated with autosomally inherited human immunodeficiency diseases. A lack of adenosine deaminase (ADA) produces severe lymphopenia and a combined immunodeficiency syndrome. A deficiency of purine nucleoside phosphorylase (PNP) is associated with a selective cellular immune depth. This article discusses the probable biochemical basis for lymphocyte-specific toxicity in these disorders.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c39e45acb1af3d71b7f85a083f0988aa https://pubmed.ncbi.nlm.nih.gov/25290650 Zobrazit plný text záznamu