Temporally Controlled Drug Delivery Systems: Coupling of pH Oscillators with Membrane Diffusion
| Autor: | Steven M. Dinh, Bret Berner, Steven A. Giannos |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Active ingredient
Time Factors Stereochemistry Oscillation Thiosulfates Pharmaceutical Science Membranes Artificial Benzoic Acid Hydrogen-Ion Concentration Sulfuric Acids Permeation Benzoates Coupling (electronics) chemistry.chemical_compound Drug Delivery Systems Membrane chemistry Drug delivery Biophysics Liberation Mathematics Benzoic acid |
| Zdroj: | Journal of Pharmaceutical Sciences. 84:539-543 |
| ISSN: | 0022-3549 |
| DOI: | 10.1002/jps.2600840505 |
| Popis: | A novel approach to modulate the release of a drug or an active ingredient that avoids the need for external power sources or electronic controllers is described. By changing the pH of a solution relative to the pKa, a drug, enhancer, or solubilizer may be rendered charged or uncharged. Because only the uncharged form of a drug can permeate across lipophilic membranes, a temporally modulated delivery profile may be obtained with a pH oscillator in the donor solution. Ionizable permeants have a buffer capacity, so the feasibility of coupling the mixed Landoldt pH oscillator with membrane diffusion of nicotine or benzoic acid is demonstrated for a single oscillation. |
| Databáze: | OpenAIRE |
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